Long-term mortality after Staphylococcus aureus spondylodiscitis: A Danish nationwide population-based cohort study - 07/08/14
, Casper Roed a, Anders R. Larsen b, Andreas Petersen b, Benny Dahl c, Peter Skinhøj a, Niels Obel aThe Danish Staphylococcal Bacteraemia Study Groupb
Summary |
Objectives |
To determine the long-term mortality and the causes of death after Staphylococcus aureus spondylodiscitis.
Methods |
Nationwide, population-based cohort study using national registries of adults diagnosed with non-postoperative S. aureus spondylodiscitis from 1994–2009 and alive 1 year after diagnosis (n = 313). A comparison cohort from the background population individually matched on sex and age was identified (n = 1565). Kaplan–Meier survival curves were constructed and Poisson regression analyses used to estimate mortality rate ratios (MRR) adjusted for comorbidity.
Results |
88 patients (28.1%) and 267 individuals from the population-based comparison cohort (17.1%) died. Un-adjusted MRR for S. aureus spondylodiscitis patients was 1.77 (95% CI, 1.39–2.25) and 1.32 (95% CI, 1.02–1.71) after adjustment for comorbidity. We observed increased mortality due to infectious (MRR 8.57; 95% CI, 2.80–26.20), endocrine (MRR 3.57; 95% CI, 1.01–12.66), cardiovascular (MRR 1.59; 95% CI, 1.02–2.49), gastrointestinal (MRR 3.21; 95% CI, 1.17–8.84) and alcohol and drug abuse-related (MRR 10.71; 95% CI, 3.23–35.58) diseases.
Conclusions |
Patients diagnosed with S. aureus spondylodiscitis have substantially increased long-term mortality, mainly due to comorbidity. To improve survival after S. aureus spondylodiscitis these patients should be screened for comorbidity and substance abuse predisposing to the disease.
Le texte complet de cet article est disponible en PDF.Keywords : Spondylodiscitis, Vertebral osteomyelitis, Long-term mortality, Prognosis, Staphylococcus aureus
Plan
Vol 69 - N° 3
P. 252-258 - septembre 2014 Retour au numéro
Article précédent
- Comparison of the clinical characteristics of diabetic and non-diabetic women with community-acquired acute pyelonephritis: A multicenter study
- Yeonjae Kim, Seong-Heon Wie, U-Im Chang, Jieun Kim, Moran Ki, Young Kyun Cho, Seung-Kwan Lim, Jin Seo Lee, Ki Tae Kwon, Hyuck Lee, Hee Jin Cheong, Dae Won Park, Seong Yeol Ryu, Moon-Hyun Chung, Hyunjoo Pai
- Predicting high vancomycin minimum inhibitory concentration isolate infection among patients with community-onset methicillin-resistant Staphylococcus aureus bacteraemia
- Shey-Ying Chen, Po-Ren Hsueh, Wen-Chu Chiang, Edward Pei-Chuan Huang, Ching-Feng Lin, Chin-Hao Chang, Shyr-Chyr Chen, Wen-Jone Chen, Shan-Chwen Chang, Mei-Shu Lai, Wei-Chu Chie
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?