Factors Associated with Neurodevelopment for Children with Single Ventricle Lesions - 23/08/14
, Minmin Lu, MS 2, Lynn A. Sleeper, ScD 2, William T. Mahle, MD 3, J. William Gaynor, MD 4, Ismee A. Williams, MD, MS 5, Kathleen A. Mussatto, PhD 6, Richard G. Ohye, MD 1, Eric M. Graham, MD 7, Deborah U. Frank, MD 8, Jeffrey P. Jacobs, MD 9, Catherine Krawczeski, MD 10, Linda Lambert, MSN 8, Alan Lewis, MD 11, Victoria L. Pemberton, RNC 12, Renee Sananes, PhD 13, Erica Sood, PhD 14, Stephanie B. Wechsler, MD 15, David C. Bellinger, PhD, MSc 16, Jane W. Newburger, MD, MPH 16on behalf of the
Pediatric Heart Network Investigators∗
Abstract |
Objective |
To measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors.
Study design |
All subjects in the Single Ventricle Reconstruction Trial who were alive without cardiac transplant were eligible for inclusion. The Ages and Stages Questionnaire (ASQ, n = 203) and other measures of behavior and quality of life were completed at age 3 years. Medical history, including measures of growth, feeding, and complications, was assessed through annual review of the records and phone interviews. The Bayley Scales of Infant Development, Second Edition (BSID-II) scores from age 14 months were also evaluated as predictors.
Results |
Scores on each ASQ domain were significantly lower than normal (P < .001). ASQ domain scores at 3 years of age varied nonlinearly with 14-month BSID-II. More complications, abnormal growth, and evidence of feeding, vision, or hearing problems were independently associated with lower ASQ scores, although models explained <30% of variation. Type of shunt was not associated with any ASQ domain score or with behavior or quality-of-life measures.
Conclusion |
Children with single right-ventricle anomalies have impaired neurodevelopment at 3 years of age. Lower ASQ scores are associated with medical morbidity, and lower BSID-II scores but not with shunt type. Because only a modest percentage of variation in 3-year neurodevelopmental outcome could be predicted from early measures, however, all children with single right-ventricle anomalies should be followed longitudinally to improve recognition of delays.
Le texte complet de cet article est disponible en PDF.Keyword : ASQ, BASC-2, BSID-II, FSII-R, HLHS, MBTS, MDI, PDI, PedsQL, QOL, RVPAS, SAE, SVR, SVR-II
Plan
| Supported by the National Heart, Lung, and Blood Institute (NHLBI; HL068269, HL068270, HL068279, HL068281, HL068285, HL068292, HL068290, HL068288, HL085057, HL109781, HL109737). The contents of the article are solely the responsibility of the authors and do not necessarily represent the official views of NHLBI or the National Institutes of Health. The authors declare no conflicts of interest. |
|
| Registered with ClinicalTrials.gov: NCT00115934. |
Vol 165 - N° 3
P. 490 - septembre 2014 Retour au numéro
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