Classifying distinct basal cell carcinoma subtype by means of dermatoscopy and reflectance confocal microscopy - 17/09/14
, Aimilios Lallas, MD a, Athanassios Kyrgidis, PhD a, Harold Rabinovitz, MD c, Elvira Moscarella, MD a, Silvana Ciardo, BS b, Iris Zalaudek, MD a, d, Margaret Oliviero, ARNP c, Amanda Losi, MD b, Salvador Gonzalez, MD e, Pascale Guitera, MD, PhD f, Simonetta Piana, MD g, Giuseppe Argenziano, MD a, Giovanni Pellacani, MD bAbstract |
Background |
The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes.
Objectives |
To define the specific dermatoscopic and confocal criteria for delineating different BCC subtypes.
Methods |
Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes.
Results |
Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n = 44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n = 22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n = 22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM.
Limitations |
The retrospective design.
Conclusion |
Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes.
Le texte complet de cet article est disponible en PDF.Key words : basal cell carcinoma, dermatoscopy, dermoscopy, diagnosis, infiltrative basal cell carcinoma, nodular basal cell carcinoma, reflectance confocal microscopy, superficial basal cell carcinoma
Abbreviations used : BCC, iBCC, nBCC, RCM, sBCC
Plan
| Supported in part by the Italian Ministry of Health (RF-2010-2316524). |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 71 - N° 4
P. 716 - octobre 2014 Retour au numéro
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