Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases - 15/10/14
, Karen H. Costenbader, MD, MPHRésumé |
Rheumatic diseases offer distinct challenges to researchers because of heterogeneity in disease phenotypes, low disease incidence, and geographic variation in genetic and environmental factors. Emerging research areas, including epigenetics, metabolomics, and the microbiome, may provide additional links between genetic and environmental risk factors in the pathogenesis of rheumatic disease. This article reviews the methods used to establish genetic and environmental risk factors and studies gene-environment interactions in rheumatic diseases, and provides specific examples of successes and challenges in identifying gene-environment interactions in rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis. Emerging research strategies and future challenges are discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Systemic lupus erythematosus, Ankylosing spondylitis, Environment, Genetics, Interaction, Smoking
Plan
| Funding: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants AR057327 and AR059073, AR066109 to Dr K.H. Costenbader). Dr J.A. Sparks was supported by the Rheumatology Research Foundation Scientist Development Award. The funders had no role in the preparation of the article. |
Vol 40 - N° 4
P. 637-657 - novembre 2014 Retour au numéro
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