Finding a Cure for Human Immunodeficiency Virus-1 Infection - 21/11/14
Doi : 10.1016/j.idc.2014.08.007
Joel N. Blankson, MD, PhD a, Janet D. Siliciano, PhD a, Robert F. Siliciano, MD, PhD a, b, ⁎ 
a Department of Medicine, Johns Hopkins University School of Medicine, 733, North Broadway, Baltimore, MD 21205, USA
b Howard Hughes Medical Institute, 733, North Broadway, Baltimore, MD 21205, USA
∗Corresponding author. Howard Hughes Medical Institute, 733, North Broadway, Baltimore, MD 21205.
Résumé |
Remarkable advances have been made in the treatment of human immunodeficiency virus (HIV)-1 infection, but in the entire history of the epidemic, only 1 patient has been cured. Herein we review the fundamental mechanisms that render HIV-1 infection difficult to cure and then discuss recent clinical and experimental situations in which some form of cure has been achieved. Finally, we consider approaches that are currently being taken to develop a general cure for HIV-1 infection.
Le texte complet de cet article est disponible en PDF.Keywords : HIV, Cure, Antiretroviral therapy, Retroviral persistence, Latent reservoir
Plan
| This work was supported by the Martin Delaney CARE and DARE Collaboratories (National Institutes of Health grants AI096113 and 1U19AI096109), by an ARCHE Collaborative Research Grant from amfAR, the Foundation for AIDS Research (108165-50-RGRL), by the Johns Hopkins Center for AIDS Research (P30AI094189), by NIH grant 43222, and by the Howard Hughes Medical Institute. |
© 2014
Elsevier Inc. Tous droits réservés.
Vol 28 - N° 4
P. 633-650 - décembre 2014 Retour au numéro
Article précédent
- Human Immunodeficiency Virus Vaccines
- Paul Goepfert, Anju Bansal
- Index
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?