Economic evaluation of appropriate duration of antibiotic prophylaxis for prevention of neurosurgical infections in a middle-income country - 04/01/15
, Emine Alp, MD, PhD a, b, Fatma Cevahir, ICN b, Bülent Tucer, MD c, Hayati Demiraslan, MD a, Ahmet Selçuklu, MD c, Mehmet Doğanay, MD aAbstract |
Background |
Preoperative antibiotic prophylaxis is one of the preventive measures for surgical site infections (SSIs). Very little data about the cost effectiveness of the appropriate duration of antibiotic prophylaxis in low- and middle-income countries are available. We aim to assess the cost effectiveness of the use of antibiotic prophylaxis for <24 hours to prevent neurosurgical infections in a middle-income country, Turkey.
Methods |
A 1-year prospective study was performed between June 2012 and June 2013. During this study period patients were followed-up on for the development of SSI by means of hospital and postdischarge surveillance. Patients included in the study group received appropriate duration of antibiotic prophylaxis (<24 hours), and the duration of prophylaxis was longer in the control group. The antibiotic costs per patient, including prophylaxis and treatment, were calculated.
Results |
A total of 822 operations consisting of craniotomy (n = 558), spinal fusion (n = 220), and ventricular shunt (n = 44) were included in the study. The study group included 488 (59.4%) patients who underwent operations with appropriate duration (<24 hours) of antibiotic prophylaxis. Prophylactic antibiotic cost per patient was significantly lower in the study group ($3.35 and $20.41, respectively). The SSI rates did not differ between the 2 groups: 3.5% (17/488) in the study group and 3.6 (12/822) in the control group (P > .05).
Conclusion |
This cost-analysis study demonstrates that prolonged antibiotic prophylaxis correlates with increased burden of cost, but it is not preventive for SSI.
Le texte complet de cet article est disponible en PDF.Key Words : Antibiotic prophylaxis, Neurosurgical infections, Cost effectiveness
Plan
| Conflicts of interest: None to report. |
Vol 43 - N° 1
P. 44-47 - janvier 2015 Retour au numéro
Article précédent
- Health care–associated methicillin-resistant Staphylococcus aureus infections increases the risk of postdischarge mortality
- Richard E. Nelson, Vanessa W. Stevens, Makoto Jones, Matthew H. Samore, Michael A. Rubin
- Surgical site infection rates in 16 cities in Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)
- Hakan Leblebicioglu, Nurettin Erben, Victor D. Rosenthal, Alper Sener, Cengiz Uzun, Gunes Senol, Gulden Ersoz, Tuna Demirdal, Fazilet Duygu, Ayse Willke, Fatma Sirmatel, Nefise Oztoprak, Iftihar Koksal, Oral Oncul, Yunus Gurbuz, Ertugrul Güçlü, Huseyin Turgut, Ata Nevzat Yalcin, Davut Ozdemir, Tanil Kendirli, Turan Aslan, Saban Esen, Fatma Ulger, Ahmet Dilek, Hava Yilmaz, Mustafa Sunbul, Ilhan Ozgunes, Gaye Usluer, Metin Otkun, Ali Kaya, Necdet Kuyucu, Zeynep Kaya, Meliha Meric, Emel Azak, Gürdal Yýlmaz, Selçuk Kaya, Hülya Ulusoy, Tuncer Haznedaroglu, Levent Gorenek, Ali Acar, Ediz Tutuncu, Oguz Karabay, Gulsume Kaya, Suzan Sacar, Hülya Sungurtekin, Do?aç U?urcan, Ozge Turhan, Sehnaz Kaya, Eylul Gumus, Oguz Dursun, Mehmet Faruk Geyik, Ahmet ?ahin, Selvi Erdogan, Erdal Ince, Adem Karbuz, Ergin Çiftçi, Nevin Ta?yapar, Melek Güne?
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