The correlation between mid-brain serotonin transporter availability and intelligence quotient in healthy volunteers - 21/01/15

Doi : 10.1016/j.eurpsy.2014.09.001

P.Y. Tseng ^a, I.H. Lee ^a,^b, K.C. Chen ^a,^b,^c, P.S. Chen ^a,^b,^c, N.T. Chiu ^d, W.J. Yao ^d, C.L. Chu ^a, T.L. Yeh ^a,^b, Y.K. Yang ^a,^b,^⁎
^a Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
^b Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
^c Department of Psychiatry, National Cheng Kung University, Dou-Liou Branch, Yunlin, Taiwan
^d Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

^⁎Corresponding author. Department of Psychiatry, National Cheng Kung University Hospital, 138, Shen Li Road, 704 Tainan, Taiwan. Tel.: +886 6 2353535x5213; fax: +886 6 2084767.

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Abstract

Purpose

This study was performed to investigate the association between the mid-brain serotonin transporter (SERT) availability and intelligence quotient (IQ).

Methods

One hundred and thirteen healthy participants, including 52 male and 61 female subjects, were recruited. We used SPECT with [¹²³I]ADAM images to determine the SERT availability in the mid-brain, and measured the subjects’ IQ using the WAIS-R.

Results

We found a significant positive correlation between the mid-brain SERT availability and the IQ of the participants. Even when controlling for age and sex, the significant association still existed.

Conclusion

This result implied that the higher the SERT binding in the mid-brain, the better the IQ in healthy participants.

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Keywords : Serotonin transporter availability, Intelligence quotient, Cognitive function, [¹²³I]ADAM, SPECT

Plan

Introduction

Materials and methods

Ethics statement

Participants

Imaging

Wechsler Adult Intelligence Scale-Revised (WAIS-R)

Statistical analysis

Results

Discussion

Disclosure of interest

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Vol 30 - N° 2

P. 193-197 - février 2015 Retour au numéro

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The correlation between mid-brain serotonin transporter availability and intelligence quotient in healthy volunteers - 21/01/15

Abstract

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