100% Uric Acid Stone Formers: What Makes Them Different? - 25/01/15
Abstract |
Objective |
To identify what risk factors on 24-hour urinalysis, if any, predispose patients to have higher percentages of uric acid (UA) stone composition in their stones, with specific emphasis on patients with pure UA stones.
Methods |
We retrospectively identified 308 patients from review of a kidney stone analysis database. Patients were grouped according to the percentage UA composition: 10%-20%, 30%-50%, 60%-90%, and 100% UA. Data were extracted from 24-hour urine collections and serum chemistries. Patients taking allopurinol, citrates, or thiazide diuretics were excluded.
Results |
The percentage UA stone composition increased as patients became older (P = .05) or heavier (P <.001). Gender did not impact the percentage of UA in stones. Although a higher serum UA level was associated with higher UA stone composition (P <.0006), urinary UA levels did not correlate (P = .1). In contrast, urinary pH correlated significantly with higher UA stone composition (P = .03).
Conclusion |
Older and heavier patients with higher serum UA levels are more likely to have a pure UA stone. This information combined with traditional predictors (urine pH, radiopacity of stone, and Hounsfield units) may help identify those most likely to respond to dissolution therapy.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
Vol 85 - N° 2
P. 296-298 - février 2015 Retour au numéro
Article précédent
- Stone Size Limits the Use of Hounsfield Units for Prediction of Calcium Oxalate Stone Composition
- Gregory Stewart, Lewis Johnson, Halemane Ganesh, Daniel Davenport, Woodson Smelser, Paul Crispen, Ramakrishna Venkatesh
- Collection and Storage of Urine Specimens for Measurement of Urolithiasis Risk Factors
- Wenqi Wu, Dong Yang, Hans-Goran Tiselius, Lili Ou, Zanlin Mai, Kang Chen, Hanliang Zhu, Shaohong Xu, Zhijian Zhao, Guohua Zeng
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