Symptomatic Management for Gastroparesis : Antiemetics, Analgesics, and Symptom Modulators - 08/02/15
Résumé |
Although prokinetic agents typically are used for gastroparesis, antiemetic, analgesic, and neuromodulatory medications may help manage nausea, vomiting, pain, or discomfort. Antiemetic benefits are supported by few case reports. An open series reported symptom reductions with transdermal granisetron in gastroparesis. Opiates are not advocated in gastroparesis because they worsen nausea and delay emptying. Neuromodulators have theoretical utility, but the tricyclic agent nortriptyline showed no benefits over placebo in an idiopathic gastroparesis study raising doubts about this strategy. Neurologic and cardiac toxicities of these medications are recognized. Additional controlled study is warranted to define antiemetic, analgesic, and neuromodulator usefulness in gastroparesis.
Le texte complet de cet article est disponible en PDF.Keywords : Antiemetic medications, Opiates, Tricyclic antidepressants, Neuropathic pain modulators, Fundus relaxants
Plan
| Disclosure statement: Dr W.L. Hasler receives research funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant U01DK073983) as part of the Gastroparesis Clinical Research Consortium. He also receives funding from Given Imaging, Inc (grant MA-501) for a clinical trial validating the WMC recording system as a diagnostic test for delayed gastric emptying. In the past 24 months, Dr W.L. Hasler has been a consultant to Janssen Pharmaceuticals, Inc; Novartis Pharmaceuticals; GSK; and Salix Pharmaceuticals, Inc. |
Vol 44 - N° 1
P. 113-126 - mars 2015 Retour au numéro
Article précédent
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