Growth and Endothelial Function in the First 2 Years of Life - 25/02/15
, Alfons J.H.M. Houben, PhD 4, 5, Frans E.S. Tan, PhD 6, 7, Marij Gielen, MD, PhD 3, 8, Maurice P. Zeegers, PhD 3, 8, Coen D.A. Stehouwer, MD, PhD 3, 4, 5, Willem-Jan M. Gerver, MD, PhD 1, 2, Klaas R. Westerterp, PhD 3, 9, Loek Wouters, BSc 3, 9, Carlos E. Blanco, MD, PhD 1, 2, Luc J. Zimmermann, MD, PhD 1, 2, Antonius L.M. Mulder, MD, PhD 1, 2Abstract |
Objective |
To test the hypothesis that the inverse association between infant growth and endothelial function at 6 months would persist to 24 months and that accelerated growth would lead to an increased percent body fat, which would, in turn, impact negatively on endothelial function.
Study design |
In a prospective observational study, 104 healthy term newborns underwent anthropometry and measurements of vascular vasodilation at 0, 6, 12, and 24 months. We recorded maximum vasodilation in response to acetylcholine (endothelium-dependent) and nitroprusside (endothelium-independent) by use of laser-Doppler vascular perfusion monitoring of the forearm skin vasculature. Additional anthropometry at 1 and 3 months was collected from child welfare centers. The data were analyzed by multilevel linear regression.
Results |
Weight gain from 0-1 month was associated inversely with maximum perfusion in response to acetylcholine at the age of 2 years (b = −8.28 perfusion units [PU] per Δ z-score, P = .03). Weight gain from 0-1 month was related positively to maximum perfusion in response to nitroprusside (b = 10.12 PU per Δ z-score, P = .04), as was birth weight (b = 8.02 PU per z-score, P = .02). Body fat percentage did not have a significant effect in any of the perfusion models and was not related to maximum perfusion at 2 years.
Conclusion |
Infant weight gain from 0-1 month is inversely related to endothelial function in healthy term infants, at least to the age of 2 years. This relationship was not explained by an increased percentage body fat.
Le texte complet de cet article est disponible en PDF.Keyword : FFM, NO, PU, TBW
Plan
| R.T. is supported by a Kootstra Fellowship from the University of Maastricht and a ‘Profileringsfonds’ grant from Maastricht University Medical Centre (PF 283). The authors declare no conflicts of interest. |
Vol 166 - N° 3
P. 666 - mars 2015 Retour au numéro
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