Induction of vascular leak syndrome by tumor necrosis factor-alpha alone - 14/03/15
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Abstract |
Although TNF-α possesses promising anticancer activity, clinical application is limited partly due to cardiovascular toxicities. TNF-α effects on vessels are likely related to vascular toxicity, but much remains poorly understood. Similarly, IL-2 is an attractive treatment option for cancers but its clinical use is limited by the side effect of vascular leak syndrome (VLS). We report here that TNF-α alone can trigger VLS. Administration of recombinant TNF-α induced VLS in normal mice and TNF-α transgenic mice exhibited VLS. Perivascular infiltrates in the lungs and specific cytokines in serum were observed in VLS-induced mice. This study shed a new light on the critical role of the TNF-α in IL-2-induced or non IL-2-induced VLS and provides important points to TNF-α therapy.
Le texte complet de cet article est disponible en PDF.Abbreviations : VLS, RA, TG
Keywords : Tumor necrosis factor-alpha, Vascular leak syndrome, Interleukin-2
Plan
Vol 70
P. 213-216 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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