Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes - 20/03/15
Abstract |
Background |
The effects of diabetes mellitus (DM) on sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography (18F-FDG PET/CT) for diagnosing pancreatic ductal adenocarcinomas (PDACs) is not well known. This study was aimed to evaluate the effects of DM on the validity of 18F-FDG PET/CT in PDAC.
Methods |
A total of 173 patients with PDACs who underwent 18F-FDG PET/CT were enrolled (75 in the DM group and 98 in the non-DM group). The maximum standardized uptake values (SUVsmax) were compared.
Results |
The mean SUVmax was significantly lower in the DM group than in the non-DM group (4.403 vs 5.998, P = .001). The sensitivity of SUVmax (cut-off value 4.0) was significantly lower in the DM group than in the non-DM group (49.3% vs 75.5%, P < .001) and also lower in normoglycemic DM patients (n = 24) than in non-DM patients (54.2% vs 75.5%, P = .038).
Conclusion |
DM contributes to a lower SUVmax of 18F-FDG PET/CT in patients with PDACs.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The SUVmax of 18F-FDG PET/CT were compared in PDAC patients with or without DM. |
• | The mean SUVmax was significantly lower in DM group than that in non-DM group. |
• | The sensitivity of SUVmax was significantly lower in DM group than that in non-DM group. |
• | DM contributes to a lower SUVmax of 18F-FDG PET/CT in patients with PDACs. |
Keywords : Carcinoma, Pancreatic ductal, Diabetes mellitus, Positron emission tomography and computed tomography, Standardized uptake value
Plan
| The authors declare no conflicts of interest. |
Vol 209 - N° 4
P. 709-716 - avril 2015 Retour au numéro
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