Optimal nutrition in infancy is the foundation of health in later life. Based on the demonstrated health benefits of human milk, breastfeeding should be the primary means of nutrition for most infants. Although many mothers experience some problems with breastfeeding, health professionals can use simple strategies to overcome most of these problems. For infants who cannot breastfeed, standard infant formulas support adequate nutrition and growth. Gastroesophageal reflux is a common feeding-related event and occurs in most infants; it is part of normal physiology and requires no intervention. Gastroesophageal reflux disease occurs in a small number of infants necessitating the use of an algorithm-based evaluation and management strategy.