Sperm Concentration Is Poorly Associated With Hypoandrogenism in Infertile Men - 27/04/15
, William O. Brant a, b, Jeremy B. Myers a, b, Chong Zhang c, Angela P. Presson c, Erica B. Johnstone d, Jessie A. Dorais d, Kenneth I. Aston a, b, d, e, Douglas T. Carrell a, b, d, e, James M. Hotaling a, bAbstract |
Objective |
To evaluate the utility of routine hormone evaluation in all men presenting for infertility by understanding the relationship between sperm concentration and hypoandrogenism.
Methods |
We performed a retrospective cross-sectional study between September 2013 and May 2014 at a tertiary referral center in Utah. Ninety-four men presenting for infertility consecutively between the ages of 18 and 55 years were identified. Our primary outcome was rate of hypoandrogenism among infertile men defined as the baseline total serum testosterone levels <300 ng/dL or bioavailable testosterone (BAT) levels <155 ng/dL. Secondary outcomes included association of normospermia, oligozoospermia, or azoospermia with biochemical or clinical hypoandrogenism.
Results |
Thirty-nine men (41%) had a total serum testosterone level of <300 ng/dL, and 41 men (43%) had a BAT level <155 ng/dL. Biochemical and symptomatic hypoandrogenism was common; 17 men (18%) had a total testosterone level <300 ng/dL and ≥3 positive Androgen Deficiency in Aging Male (ADAM) responses, and 18 men (19%) had a BAT level of <155 ng/dL and ≥3 positive ADAM responses. Sperm concentration (normospermia, oligozoospermia, and azoospermia) was not associated with biochemical hypoandrogenism (total testosterone level <300 ng/dL or BAT level <155 ng/dL), symptomatic hypoandrogenism (≥3 positive ADAM responses), or sexual dysfunction (Sexual Health Inventory for Men score <21).
Conclusion |
Hypoandrogenism is common among infertile men, and routine hormonal evaluation may identify hypoandrogenism in many infertile men with otherwise normal semen analysis. Sperm concentration (normospermia, oligozoospermia, and azoospermia) is not well associated with hypoandrogenism in infertile men.
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| Financial Disclosure: Darshan P. Patel was supported in part by a generous reconstructive urology educational grant from American Medical Systems, Inc., Minnetonka, MN. The remaining authors declare that they have no relevant financial interests. |
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| American Medical Systems, Inc. had no role in study concept, design, data acquisition and analysis, or article drafting and revision. |
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| Darshan P. Patel and James M. Hotaling made substantial contributions to research design, data acquisition, analysis, drafting and revising of the article, and final approval of submission; Chong Zhang and Angela P. Presson contributed to data analysis and interpretation; William O. Brant, Jeremy B. Meyers, Erica B. Johnstone, Jessie A. Dorais, Kenneth I. Aston, and Douglas Carrell contributed to critically revising and final approval of the submitted article. |
Vol 85 - N° 5
P. 1062-1067 - mai 2015 Retour au numéro
Article précédent
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