Solifenacin or Mirabegron Could Improve Persistent Overactive Bladder Symptoms After Dutasteride Treatment in Patients With Benign Prostatic Hyperplasia - 27/04/15
, Masanori Hasegawa a, Katsura Ishioka a, Masayuki Hagiwara a, Yasumasa Miyazaki a, Toshiaki Shinojima a, Akira Miyajima a, Mototsugu Oya aAbstract |
Objective |
To evaluate the clinical response and adverse events (AEs) of solifenacin (SOL) or mirabegron (MIR) in benign prostatic hyperplasia patients with persistent overactive bladder (OAB) symptoms after dutasteride (DUT) treatment.
Methods |
Fifty cases with residual OAB symptom score (OABSS) ≥5 and OABSS Q3 ≥2 after at least 6 months treatment of DUT were included in this study. Patients were administered 5 mg/d of SOL (N = 25) or 50 mg/d of MIR (N = 25), and International Prostate Symptom Score (IPSS) and OABSS were prospectively collected at 4 and 12 weeks. The safety was evaluated by changes in postvoided residual urine volume and the incidence of AEs.
Results |
After DUT administration, the mean prostate volume, IPSS, and OABSS were 39.0 mL, 17.6, and 8.1, respectively. SOL 5 mg significantly reduced the IPSS, OABSS, and OABSS Q3 at 4 and at 12 weeks (−3.1, −2.7, −1.3; P <.05); however, 4 patients could not continue the SOL treatment owing to AEs. All patients could continue the 12 weeks of MIR treatment, and MIR 50 mg reduced IPSS and OABSS at 4 weeks and reduced IPSS, OABSS, and the OABSS Q3 (−3.0, −2.5, −0.9; P <.05) at 12 weeks. Postvoided residual urine volume increased by ≥100 mL after treatment in 2 cases in the SOL group but not in any patient in the MIR group.
Conclusion |
Additional SOL or MIR might result in amelioration of the persistent OAB symptom after DUT treatment in patients with an enlarged prostate.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
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| Funding Support: This work was supported in part by Grant-in-Aid for Young Scientists (B) (#25861453) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. |
Vol 85 - N° 5
P. 1151-1155 - mai 2015 Retour au numéro
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