Hyperpolarized Gas MR Imaging : Technique and Applications - 06/05/15
, Holman P. McAdams, MD a, S. Sivaram Kaushik, PhD b, c, Bastiaan Driehuys, PhD cRésumé |
Functional imaging offers information more sensitive to changes in lung structure and function. Hyperpolarized helium (3He) and xenon (129Xe) MR imaging of the lungs provides sensitive contrast mechanisms to probe changes in pulmonary ventilation, microstructure, and gas exchange. Gas imaging has shifted to the use of 129Xe. Xenon is well-tolerated. 129Xe is soluble in pulmonary tissue, which allows exploring specific lung function characteristics involved in gas exchange and alveolar oxygenation. Hyperpolarized gases and 129Xe in particular stand to be an excellent probe of pulmonary structure and function, and provide sensitive and noninvasive biomarkers for pulmonary diseases.
Le texte complet de cet article est disponible en PDF.Keywords : MR imaging, Lung imaging, Hyperpolarized gas, Pulmonary ventilation, Pulmonary gas exchange, Xenon (129Xe)
Plan
| Dr B. Driehuys is a founder and shareholder of Polarean, Inc. Dr J.E. Roos, Dr H.P. McAdams, and Dr S.S. Kaushik have nothing to disclose. This work was funded by NIH/NHLBI R01 HL105643 with additional support from the Duke Center for In Vivo Microscopy, an NIH/NIBIB national Biomedical Technology Resource Center (P41 EB015897). |
Vol 23 - N° 2
P. 217-229 - mai 2015 Retour au numéro
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