Nervous System Lyme Disease - 20/05/15
Résumé |
Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.
Le texte complet de cet article est disponible en PDF.Keywords : Lyme disease, Borrelia burgdorferi, Neuroborreliosis, Garin-Bujadoux Bannwarth syndrome, Nervous system, Peripheral nervous system, Central nervous system, Intrathecal antibody
Plan
| Disclosures: The author has been an expert witness defending physicians in medical malpractice cases in which they have been accused of failure to diagnose or treat Lyme disease; the author has equity in several pharmaceutical companies, none of which is relevant to this topic. The author receives royalties from Up-to-date and Lyme Disease: an Evidence-based Approach, published by CABI in 2011. |
Vol 29 - N° 2
P. 241-253 - juin 2015 Retour au numéro
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