Rotavirus - 24/05/15
Résumé |
Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus strains in stool samples for proper patient treatment and to monitor circulating vaccine and wild-type rotavirus strains. New molecular assays are rapidly developed that are more sensitive and specific than the conventional assays for detection, genotyping and full genome characterization of circulating rotavirus wild-type and vaccine (Rotarix® and RotaTeq®) strains causing AGE.
Le texte complet de cet article est disponible en PDF.Keywords : Rotavirus, Acute gastroenteritis, Rotavirus vaccines, Rotarix®, RotaTeq®, qRT-PCR, Multiplex assays, Next-generation sequencing
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| Conflict of Interest Statement: The authors declare that they have no financial, professional, or personal conflicts of interest. |
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| Disclaimer: The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Names of specific vendors, manufacturers, and products are included for public health and informational purposes; inclusion does not imply endorsement of the vendors, manufacturers, and products by the Centers for Disease Control and Prevention or the US Department of Health and Human Services. |
Vol 35 - N° 2
P. 363-391 - juin 2015 Retour au numéro
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