Intestinal Amebae - 24/05/15

Doi : 10.1016/j.cll.2015.02.009

Ibne Karim M. Ali, PhD
Division of Foodborne Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Mailstop D-66, Atlanta, GA 30329, USA

Résumé

Among the Entamoeba species that infect humans, Entamoeba histolytica causes diseases, Entamoeba dispar is a harmless commensal, Entamoeba moshkovskii seems to be a pathogen, and the pathogenicity of Entamoeba bangladeshi remains to be investigated. Species-specific detection needed for treatment decisions and for understanding the epidemiology and pathogenicity of these amebae. Antigen-based detection methods are needed for E dispar, E moshkovskii, and E bangladeshi; and molecular diagnostic test capable of detecting E histolytica, E dispar, E moshkovskii, and E bangladeshi simultaneously in clinical samples. Next-generation sequencing of DNA from stool is needed to identify novel species of Entamoeba.

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Keywords : Amebiasis laboratory diagnosis, Entamoeba histolytica, Entamoeba dispar, Entamoeba moshkovskii, Entamoeba Bangladeshi, Serology, Antigen detection, Molecular detection

Plan

	Conflicts of interest: The author has no conflicts of interest.
	Search strategy and selection criteria: References for this article were identified through searches of PubMed, by use of the search terms “amebiasis,” “Entamoeba histolytica,” “Entamoeba dispar,” “Entamoeba moshkovskii,” “Entamoeba bangladeshi,” “diagnosis,” “molecular tools,” and combinations of these terms. The search was mostly limited to English language articles that were published up to December 2014.
	Disclaimer: The use of trade names is for identification only and does not imply the endorsement of the US Centers for Disease Control and Prevention (CDC). The findings and conclusions in this article are those of the author, and do not necessarily represent the official position of the CDC.