miR-217 targeting Wnt5a in osteosarcoma functions as a potential tumor suppressor - 08/06/15
, Zhouming Deng b, 1, Jiajia Su cBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults, however roles of microRNAs (miRNAs) in OS is still unclear. miR-217 is recently widely studied in various cancers, but not including OS. This study is aimed to investigate the expression and cellular function of miR-217 in OS. The data showed that miR-217 expression was consistently lower in OS tissues and cell lines than the normal controls. Restoration of miR-217 expression in MG-63 and U2OS cells could inhibit cell proliferation, migration and invasion, and induced apoptosis. Bioinformatic prediction suggested that Wnt5a is a target gene of miR-217. Using luciferase assay, mRNA and protein expression analysis, it was verified that Wnt5a was a target gene of miR-217 in OS cells. Restored expression of Wnt5a weakened miR-217-mediated suppression of tumor progression. Taken together, our data indicate that miR-217 functions as a tumor suppressor in OS by suppressing Wnt5a expression.
Le texte complet de cet article est disponible en PDF.Keywords : miR-217, Osteosarcoma, Wnt5a, Tumor progression
Plan
Vol 72
P. 158-164 - mai 2015 Retour au numéro
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