Clinical outcomes of chronic kidney disease patients treated with everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) - 08/06/15
, Takao Shimohama c , Yuki Ikeda a , Sayaka Namba a , Takehiro Hashikata a , Ryo Kameda c , Nobuhiro Sato c , Ichiro Takeuchi c , Minako Yamaoka-Tojo b , Taiki Tojo c, ⁎ , Junya Ako a, c Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background |
The target lesion revascularization of paclitaxel-eluting stents (PES) has been reported to be lower than that of sirolimus-eluting stents in patients on hemodialysis (HD). However, the comparison of PES and second generation drug-eluting stents in CKD patients has not been fully investigated. We compared clinical outcomes of everolimus-eluting stents (EES) and PES in CKD patients.
Methods |
Hundred and forty seven CKD patients (eGFR<60mLmin−11.73m−2) treated with PES (n=74, from May 2007 to December 2009) and EES (n=73, from January 2010 to January 2013) were enrolled in the study. Major adverse cardiac events (MACEs) were defined as death, non-fatal myocardial infarction, and ischemia driven target lesion revascularization.
Results |
The incidence of 36-month MACE was significantly lower in EES, non-HD group compared to PES, non HD group (0% in EES group and 13.5% in PES group, respectively, P<0.01). There was no significant difference in MACE between EES and PES in HD patients (5.4% in PES group and 5.5% in EES group, P=0.98). In multivariate analysis, PES group and PES ISR were independent factors for worse incidence of MACE.
Conclusions |
In CKD patients, PES was associated with worse clinical outcomes in non-HD patients as compared with EES.
Le texte complet de cet article est disponible en PDF.Keywords : Everolimus-eluting stent, Paclitaxel-eluting stent, Chronic kidney disease
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Vol 72
P. 6-10 - mai 2015 Retour au numéro
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