A preliminary study on surgery for hepatocellular carcinoma patients with portal hypertension - 12/06/15
Abstract |
Background |
To assess the effects of various operations for hepatocellular carcinoma with portal hypertension (PH).
Methods |
Data regarding 78 patients with resectable liver cancer with PH were analyzed. Patients were divided into 3 groups: A (splenic artery ligation), B (in situ splenectomy), and C (in situ splenectomy + pericardial devascularization).
Results |
White blood cell and platelet counts in the 3 groups increased significantly after surgery. Postoperative portal pressure was not significantly lower than preoperative portal pressure in Group A, while it was significantly lower in B. In Group C, the portal pressure after splenectomy was significantly lower than that before the operation, but not again after pericardial devascularization. The 1-, 2-, and 3-year survival rates of all the patients were 89.7%, 64.1%, and 46.1%, respectively.
Conclusions |
PH is not an absolute contraindication to liver resection in Child–Pugh class B cirrhotic patients. The combined surgery for hepatocellular carcinoma patients with PH is a safe choice.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This study aimed to assess the effects of various operations for HCC with PH. Data regarding 78 patients with resectable liver cancer with PH were analyzed. Patients were divided into 3 groups: A (splenic artery ligation), B (in situ splenectomy), and C (in situ splenectomy + pericardial devascularization). WBC and platelet counts in 3 groups increased significantly after surgery. Postoperative portal pressure was not significantly lower than preoperative portal pressure in Group A, while it was significantly lower in B. In Group C, the portal pressure after splenectomy was significantly lower than that before the operation, but not again after pericardial devascularization. The 1-, 2-, and 3-year survival rates of all the patients were 89.7%, 64.1%, and 46.1%, respectively. It was concluded that PH is not an absolute contraindication to liver resection in Child–Pugh class B cirrhotic patients. The combined surgery for HCC patients with PH is a safe choice. |
Keywords : Hepatocellular carcinoma, Cirrhosis, Portal hypertension, Surgery
Plan
| Supported by funds from the 2013 Applied Basic Research of Changzhou Bureau of Science and Technology provided by Y.-F.D. and Jiangsu Health International Exchange Supporting Program provided by X.-D.L. |
|
| The authors declare no conflicts of interest. |
Vol 210 - N° 1
P. 129-133 - juillet 2015 Retour au numéro
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