Sympathetic Activity Assessed during Exercise Recovery in Young Obese Females - 23/07/15
, Stacey H. Privett, MS 1, Mary K. Bowen, MS 1, Edmund O. Acevedo, PhD 1, James A. Arrowood, MD 2, Edmond P. Wickham, MD 3, Ronald K. Evans, PhD 1Abstract |
Objective |
To evaluate differences in sympathetic activity, as assessed by an exercise recovery index (ERI; heart rate/oxygen consumption [VO2] plateau), between black and white obese female adolescents. An additional aim was to determine the association of ERI with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), cardiovascular fitness per fat-free mass (VO2 per fat-free mass), systolic blood pressure (SBP), and percent body fat (%FAT) in both black and white obese adolescents.
Study design |
Sixty-one females volunteered to participate in this study. HOMA-IR, SBP, and %FAT were assessed during resting conditions in black (n = 49, 13.7 ± 1.6 years, 38.1 ± 6.1 kg/m2) and white (n = 12, 13.3 ± 2.2 years, 34.3 ± 4.9 kg/m2) obese adolescents. An ERI was calculated during a 5-minute passive recovery period immediately following a graded treadmill exercise test to exhaustion.
Results |
The ERI was significantly greater in black compared with white obese adolescent females (29.8 ± 6.4 vs 24.1 ± 3.1 bpm·mLO2−1·min−1, P = .004). Using multiple linear regression modeling, there was a significant independent association between ERI and VO2 per fat-free mass (r = −0.310, P = .027) and %FAT (r = 0.326, P = .020) in black obese adolescents after controlling for HOMA-IR and SBP.
Conclusions |
These results suggest that black obese adolescent females have greater sympathetic activity, as assessed by an ERI, than white obese adolescent females. These findings support the need for weight management efforts aimed at both reducing %FAT and improving fitness in obese adolescents, specifically black females.
Trial registration |
Registered with Clinicaltrials.gov: NCT00562293
Le texte complet de cet article est disponible en PDF.Keyword : %FAT, ANS, BMI, ERI, HDL, HOMA-IR, HR, IR, LDL, PNS, SBP, SNS, TAG, VO2, VO2FFM
Plan
| Supported by Virginia Premier Health Plan, Inc, Children's Hospital Foundation, the National Institutes of Health CTSA (K23-HD053742 [to E.W.] and UL1TR000058 [to V.U.]). The authors declare no conflicts of interest. |
Vol 167 - N° 2
P. 378 - août 2015 Retour au numéro
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