Eosinophilia in Hematologic Disorders - 24/07/15

Résumé |
Eosinophilia in the peripheral blood can be the manifestation various medical conditions, including benign or malignant disorders. There are 3 main types of eosinophilia-associated myeloid neoplasms (MN-eos): myeloid and lymphoid neoplasms, chronic eosinophilic leukemia not otherwise specified, and idiopathic hypereosinophilic syndrome (HES). Imatinib mesylate has revolutionized the treatment of molecularly defined MN-eos, and novel agents have been successfully used to treat HES. The discovery of new, recurrent molecular alterations in patients with MN-eos may improve their diagnosis and therapy. This review focuses on the hematologist’s approach to a patient with eosinophilia and treatment options for those with eosinophilic myeloid neoplasms.
Le texte complet de cet article est disponible en PDF.Keywords : Eosinophilia, PDGFRA, PDGFRB, Chronic eosinophilic leukemia, Hypereosinophilic syndrome, Imatinib
Plan
| The authors have nothing to disclose. |
Vol 35 - N° 3
P. 439-452 - août 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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