Preventing Diabetic Ketoacidosis - 24/07/15

Doi : 10.1016/j.pcl.2015.04.002

Craig A. Jefferies, MBChB, MD ^a,^b,^⁎,^{^{1
Coprimary authors.}} , Meranda Nakhla, MSc, MD, FRCPC ^c,^{^{1
Coprimary authors.}}, José G.B. Derraik, PhD ^b, Alistair J. Gunn, MBChB, PhD ^a,^d, Denis Daneman, MBBCh, FRCPC, DSc (Med) ^e, Wayne S. Cutfield, MBChB, MD ^a,^b
^a Paediatric Endocrinology Service, Starship Children's Hospital, Auckland District Health Board, 2 Park Road, Auckland, 1023, New Zealand
^b Liggins Institute, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand
^c Department of Paediatrics, Montreal Children’s Hospital, McGill University, 2300 Tupper Street, H3H 1P3, Montreal, Canada
^d Department of Physiology, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand
^e Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Canada

^∗Corresponding author. Starship Children's Health, Private Bag 92024, Auckland 1142, New Zealand.

Résumé

Diabetic ketoacidosis (DKA) is a major cause of morbidity and mortality in children with type 1 diabetes mellitus (T1DM). This article examines the factors associated with DKA in children with T1DM, both at first presentation and in recurrent cases. The challenge for future research is to find effective ways to improve primary care physician and general community awareness of T1DM to reduce DKA at presentation and develop practical, cost-effective programs to reduce recurrent DKA.

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Keywords : Type 1 diabetes mellitus, Diabetic ketoacidosis, Prevention, Education, Recurrent, Noncompliance, Girls