A Population-Based Imaging Genetics Study of Inattention/Hyperactivity: Basal Ganglia and Genetic Pathways - 21/08/15
Abstract |
Objective |
Although attention-deficit/hyperactivity disorder (ADHD) is 1 of the most common neurodevelopmental disorders, little is known about the neurobiology. Clinical studies suggest basal ganglia morphology plays a role. Furthermore, hyperactivity/impulsivity symptoms have recently been linked to genetic pathways involved in dopamine/norepinephrine and serotonin neurotransmission and neuritic outgrowth. We aimed to assess the association between ADHD symptoms, basal ganglia volume, and the 3 proposed genetic pathways in a pediatric population-based sample. With this, we aimed to investigate the generalizability of earlier clinical findings to the general population.
Method |
This study included a population-based sample of 1,871 children with data on ADHD symptoms and genetic data, and 344 children with additional neuroimaging data. Regression analyses between ADHD symptom severity and volumetric data of the basal ganglia were performed. Also, gene-set analyses investigating the association between both ADHD symptom severity and basal ganglia volume with the dopamine/norepinephrine, serotonin, and neuritic outgrowth pathways were performed.
Results |
More inattention and hyperactivity/impulsivity symptoms were associated with a smaller volume of the putamen (β = –0.13, p = .034), which was regarded as trend-level after correction for multiple testing. Stratified analyses showed a stronger putamen–hyperactivity association in children with clinical scores, although a similar trend was visible in the nonclinical subsample. The genetic pathways were not related to either ADHD symptoms or basal ganglia volume.
Conclusion |
ADHD symptoms were marginally related to putamen volume in our population-based sample. We found no evidence for a role of dopamine/norepinephrine, serotonin, or neuritic outgrowth genetic pathways in ADHD symptom severity.
Le texte complet de cet article est disponible en PDF.Key Words : attention-deficit/hyperactivity problems, gene sets, neurotransmitter systems, neuroimaging, basal ganglia
Plan
| This article is discussed in an editorial by Drs. Philip Asherson and Paul F. O'Reilly on page 702. |
|
| This article was reviewed under and accepted by ad hoc editor Guido K.W. Frank, MD. |
|
| This study is financially supported through the Netherlands Organisation for Scientific Research (NWO) and the Netherlands Organisation for Health Research and Development (ZonMw) (TOP project number 91211021), NWO Vici (project number 453-14-005), and the NWO Brain and Cognition (project number 433-09-228). The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, NWO, and the Ministry of Health, Welfare and Sport (formerly the Ministry for Youth and Families). |
|
| The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. The Generation R Study is conducted by the Erasmus Medical Center in collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, the Rotterdam Homecare Foundation, and the Stichting Trombosedienst en Artsenlaboratorium Rijnmond (STARMDC) in Rotterdam. |
|
| Disclosure: Dr. Verhulst has received remuneration as contributing author of the Achenbach System of Empirically Based Assessment (ASEBA). Drs. Polderman, Tiemeier, van der Lugt, Jaddoe, Hofman, White, Posthuma, and Mss. Mous and Hammerschlag report no biomedical financial interests or potential conflicts of interest. |
Vol 54 - N° 9
P. 745-752 - septembre 2015 Retour au numéro
Article précédent
- Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis
- Irene Pappa, Iryna O. Fedko, Viara R. Mileva-Seitz, Jouke-Jan Hottenga, Marian J. Bakermans-Kranenburg, Meike Bartels, Catharina E.M. van Beijsterveldt, Vincent W.V. Jaddoe, Christel M. Middeldorp, Ralph C.A. Rippe, Fernando Rivadeneira, Henning Tiemeier, Frank C. Verhulst, Marinus H. van IJzendoorn, Dorret I. Boomsma
- Child Maltreatment and Neural Systems Underlying Emotion Regulation
- Katie A. McLaughlin, Matthew Peverill, Andrea L. Gold, Sonia Alves, Margaret A. Sheridan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?