Restless Legs Syndrome and Cognitive Function: A Population-based Cross-sectional Study - 31/08/15
Abstract |
Background |
Restless legs syndrome has been speculated to be linked to cognitive impairment through vascular risk factors or through its effect on sleep deprivation. Previous studies on the association between restless legs syndrome and cognitive function have been inconclusive. We performed a cross-sectional analysis of the association between restless legs syndrome and cognitive function using data from a large population-based study of elderly individuals residing in France.
Methods |
We used information from 2070 individuals from the Dijon, France center of the Three-City study who had available information on restless legs syndrome and cognitive functioning measures. Restless legs syndrome was assessed using the 4 minimal diagnostic criteria of the International Restless Legs Study Group. During the same wave in which restless legs syndrome status was assessed, cognitive functions also were assessed using 4 tests: Isaacs' test of verbal/category fluency, the Benton Visual Retention Test, the Trail Making Test B, and the Mini-Mental State Examination. We created a summary global cognitive score by summing the z scores for the 4 tests and used analysis of covariance to explore the association between restless legs syndrome and cognitive function.
Results |
We did not observe any statistically significant differences in any cognitive z-score between those with restless legs syndrome and those without restless legs syndrome. The mean global z-score after multivariate adjustment was −0.003 (SE 0.173) for those with restless legs syndrome and −0.007 (SE 0.129) for those without restless legs syndrome (P-value = .98).
Conclusion |
Data from this large, population-based study do not suggest that restless legs syndrome is associated with prevalent cognitive deficits in elderly individuals.
Le texte complet de cet article est disponible en PDF.Keywords : Cognitive function, Epidemiology, Restless legs syndrome
Plan
| Funding: The Three-City Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the Victor Segalen–Bordeaux II University, and the Sanofi-Synthélabo Company. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The Three-City Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Haute Autorité de la Santé, Institut National de Prévention et d'Education pour la Santé, Conseils Régionaux of Bourgogne, Fondation de France, Ministry of Research-INSERM Program “Cohortes et collections de données biologiques,” Mutuelle Générale de l'Education Nationale, Institut de la Longévité, Conseil Général de la Côte d'or. Pamela M. Rist was supported by the Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics from the Harvard School of Public Health. |
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| Conflict of Interest: PMR has received, within the last 2 years, funding from the Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics from the Harvard School of Public Health. AE has received, within the last 2 years, investigator-initiated research funding unrelated to this project from the French National Research Agency, EU Joint Programme–Neurodegenerative Disease Research (JPND), the French Agency for Drug Security (ANSM), and the French Institute for Research in Public Health (IRESP). CD has received honoraria from the American Academy of Neurology for educational lectures and from Eisai, Inc. for providing methodological expertise. CT has received fees from the Fondation Plan Alzheimer, the Fondation de Recherche sur l'Hypertension Artérielle, and ABBOTT for participating in scientific committees. He has also received investigator-initiated research funding from the French National Research Agency (ANR) and the Fondation Plan Alzheimer for the Three-City study. TK has received, within the last 2 years, investigator-initiated research funding from the French National Research Agency, and the US National Institutes of Health. Further, he has received honoraria from the American Academy of Neurology for educational lectures and from the BMJ and Cephalalgia for editorial services. |
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| Authorship: All authors had access to the data and a role in writing the manuscript. |
Vol 128 - N° 9
P. 1023.e33-1023.e39 - septembre 2015 Retour au numéro
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