The adrenal glands are a common site for primary benign and malignant tumors and metastatic disease. Computed tomography (CT), MR imaging, and fluorine-18 fluorodeoxyglucose PET combined with CT are the most common imaging modalities used to assess the adrenal glands. There are established morphologic criteria for both CT and MR imaging that can be used to assess whether an adrenal mass is benign or malignant, and whether follow-up, biopsy, or resection should be performed. In the setting of a known primary malignancy, CT, MR imaging, and PET can help differentiate most benign masses from metastasis.