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Médecine et maladies infectieuses
Volume 50, n° 1
pages 43-48 (février 2020)
Doi : 10.1016/j.medmal.2019.04.001
Received : 6 September 2017 ;  accepted : 1 April 2019

HIV-infected patients aged above 75years
Patients de plus de 75 ans vivant avec le VIH

C. Bernaud a, , S. Sécher a, b, C. Michau c, P. Perre d, P. Fialaire e, R. Vatan f, F. Raffi a, C. Allavena a, H. Hitoto g
a Hôtel-Dieu university hospital, infectious and tropical disease department, 44000 Nantes, France 
b COREVIH Pays de la Loire, Nantes university hospital, 44000 Nantes, France 
c Saint-Nazaire hospital, internal medicine department, Saint-Nazaire, 44600 Saint-Nazaire, France 
d Departmental hospital, post-emergency department medicine unit, 85000 La Roche-sur-Yon, France 
e Angers hospital, infectious and tropical disease department, 49000 Angers, France 
f Laval hospital, internal medicine department, 53000 Laval, France 
g Le Mans hospital, infectious and tropical disease department, 72000 Le Mans, France 

Corresponding author. Service de maladies infectieuses, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.Service de maladies infectieuses, CHU de Nantes1, place Alexis-RicordeauNantes44000France

We performed a multicenter observational study of HIV-infected individuals aged 75years and above, i.e. a poorly studied population. The study assessed immuno-virological and therapeutic data, and highlighted the excellent follow-up of these patients. We also suggested a simplified geriatric evaluation to screen for frailty in these patients, and we underlined underdiagnosed and poorly treated frailty factors such as depression, cognitive disorders, undernourishment, vitamin D deficiency, and pain.

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Little data is available on HIV-infected patients aged over 75years.


A descriptive study of HIV-infected patients aged over 75years was conducted in six hospitals of the Pays de la Loire region, France. Socio-demographic, immuno-virological, and therapeutic characteristics were collected via an electronic medical record software (Nadis®). To assess frailty, a simplified geriatric assessment was conducted during an HIV routine visit.


Among the 3965 patients followed in the six centers, 65 (1.6%) were aged over 75years. From January to May 2016, 51 patients were included in the study: median age 78.7years, male patients 74.5%, homosexual transmission 41.2%, living at home 98% and single in 54.5% of cases, median duration of HIV infection 18.8years, median CD4 nadir 181 cells/mm3; CDC stage C 36.4%. All patients were on antiretroviral therapy and 98% of them had an HIV RNA<50c/mL; 82% of patients had at least one comorbidity and 58% at least two comorbidities. Eleven of 51 patients (21.6%) were diagnosed as at risk of frailty and 2/51 (3.9%) were considered frail. Cognitive disorders were diagnosed in 60.8%, depression in 35.3%, malnutrition in 25.5%, and vitamin D deficiency in 45.9%.


HIV-infected patients aged above 75years are well-managed, but the prevalence of geriatric comorbidities is high.

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Peu de données sont disponibles sur les PVVIH˃75 ans.


Étude descriptive transversale des PVVIH75 ans dans les six centres hospitaliers des Pays de la Loire. Les caractéristiques épidémiologiques, immuno-virologiques et thérapeutiques de cette population ont été recueillies via un logiciel de dossier médical informatisé et une évaluation gériatrique standardisée simplifiée a été réalisée en parallèle pour évaluer la vulnérabilité de ces patients.


Parmi la file active des six services, 65/3965 patients (1,64 %) avaient˃75 ans. Parmi ces 65 patients, 51 ont eu une consultation pendant la période d’étude et ont été inclus (âge médian 78,7 ans ; 74,5 % d’hommes ; 41,2 % infectés par contamination homosexuelle ; 98 % vivant à domicile et célibataire dans 57 % des cas ; durée médiane de l’infection à VIH : 18,8 ans ; nadir de CD4 médian 181/mm3). Tous les patients étaient sous TARV et 98 % avaient une charge virale indétectable (<50 copies/mL) ; 82 % des patients avaient au moins une comorbidité et 58 % au moins deux. Selon une évaluation gériatrique simplifiée : 21,6 % apparaissaient en voie de fragilité et 3,9 % comme fragiles ; 60,8 % avaient des troubles cognitifs, 35,3 % présentaient une dépression, 25,5 % une dénutrition, 45,9 % un déficit en vitamine D.


Les PVVIH75 ans sont bien suivis et contrôlés pour l’infection à VIH mais la prévalence de comorbidités gériatriques est importante.

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Keywords : HIV, Aging, Geriatric assessment

Mots clés : VIH, Vieillissement, Évaluation gériatrique

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