Substance use and the course of early psychosis: a 2-year follow-up of first-admitted subjects - 01/01/03
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Résumé |
Objective. - To examine the impact of alcohol and substance use on the early course of psychosis.
Methods: First-admitted subjects with psychosis (n = 58) were assessed at 6-month intervals over a 2-year follow-up. Information on substance and alcohol misuse and clinical and social outcome was collected using multiple sources of information.
Results. - After adjustment for potential confounding factors, subjects with persistent substance misuse over the follow-up were at increased risk of readmission (OR = 3.1; 95%CI = 1.0-9.4; P = 0.05), of presenting with psychotic symptoms (OR = 4.3; 95%CI = 1.0-18.1; P = 0.04), and with a non-continuous course of illness (OR = 11; 95%CI = 1-122; P = 0.05). No significant association was found between substance misuse and social outcome, or between alcohol misuse and clinical and social outcome.
Conclusion. - Persistent substance misuse after a first admission for psychosis has a deleterious impact on clinical outcome. Early identification and treatment of substance use is essential in the care of subjects with incipient psychosis.
Mots clés : Psychosis ; First episode ; Substance use ; Outcome.
Plan
Vol 18 - N° 3
P. 133-136 - mai 2003 Retour au numéro
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