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Revue du rhumatisme
Volume 69, n° 1
pages 76-79 (janvier 2002)
Received : 7 February 2001 ;  accepted : 12 June 2001
Silicose pulmonaire et lupus érythémateux disséminé chez l'homme. À propos de deux observations
Pulmonary silicosis and systemic lupus erythematosus in men: a report of two cases.

Lilian Tereza Lavras  Costallat * ,  Eduardo Mello  De Capitani,  Lair  Zambon
Département de médecine, division de pneumologie et division de rhumatologie, université des Sciences médicales, université d'État de Campinas, Sao Paulo, Brésil 

*Correspondance et tirés à part : Departemento de Clinica Médica, Faculdade de Ciencas Médicas UNICAMP, Campinas Sao Paulo CEP 13083-970, Brazil

Nous rapportons deux cas d'association entre silicose pulmonaire et lupus érythémateux disséminé (LED). Les deux hommes atteints de LED avaient été exposés à la silice pendant 20 ans. L'hypothèse d'une association entre l'exposition à la silice et la survenue de diverses maladies auto-immunes, incluant le LED, a été discutée au cours de la dernière décennie, mais peu de cas d'association entre LED et silicose pulmonaire ont été rapportés. Notre but a été d'attirer l'attention sur l'hypothèse qui semble de plus en plus probable, selon laquelle la silice peut aussi entraîner ou déclencher un LED, ainsi que sur la nécessité d'étudier plus à fond le rôle de l'exposition professionnelle, principalement chez les hommes atteints de LED.

Mots clés  : lupus érythémateux disséminé ; maladie professionnelle ; silicose pulmonaire.


We report two cases of coexistence of pulmonary silicosis and systemic lupus erythematosus (SLE). The patients are two men with SLE exposed to silica for 20 years.The hypothesis that silica exposure is linked to a wide variety of known or suspected autoimmune diseases, include SLE, has been discussing in the last decade but few cases of pulmonary silicosis and SLE were reported. Our purpose was to bring attention to the increasing evidence that silica may also cause or stimulate SLE, and to suggest that the researchers looked for the occupational exposure, mainly in male SLE patients.

Mots clés  : pulmonary silicosis ; occupational disease ; silica ; systemic lupus.

© 2002  Éditions scientifiques et médicales Elsevier SAS. All Rights Reserved.

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