The successful use of injectable collagen, a xenogeneic material indicated as a tissue replacement for correcting certain soft tissue anomalies, depends primarily on appropriate lesion selection and proper technic. Treatment with injectable collagen yields best results in soft, distensible lesions with relatively smooth margins. Lesions most amenable to correction include acne scars, steroid- or disease-induced areas of atrophy, glabellar furrows, nasolabial lines, postrhinoplasty irregularities, and depressed skin grafts. Optimal correction with the fewest number of injections is chiefly dependent upon deliberate overcorrection and superficial intradermal placement of the material. Outlined here are my experiences with over 1,000 patients treated with injectable collagen for a variety of soft tissue deficiencies.