Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis - 23/05/18
Monocytes dans le LCS au cours des méningites bactériennes, virales et neuroborrélioses
, V. Greigert a, L. Souply b, B. Rosolen a, D. De Briel b, M. Mohseni Zadeh a, J.-D. Kaiser cBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Highlights |
• | CSF leukocyte count and formula are commonly used to differentiate bacterial meningitis, viral meningitis, and neuroborreliosis. |
• | CSF lymphocytes and PMNs are easy to interpret, but CSF monocytes may be confusing for physicians. |
• | We collected the results of 200 patients presenting with clearly defined meningitis and demonstrated that the proportions of monocytes in CSF — although highest in viral meningitis —are not useful to discriminate between the three types of meningitis due to value overlap. |
Abstract |
Objective |
Cerebrospinal fluid (CSF) leukocytes analysis is commonly used to diagnose meningitis and to differentiate bacterial from viral meningitis. Interpreting CSF monocytes can be difficult for physicians, especially in France where lymphocytes and monocytes results are sometimes pooled.
Patients and methods |
We assessed SF monocytes in patients presenting with microbiologically confirmed meningitis (CSF leukocyte count>10/mm3 for adults or >30/mm3 for children<2 months), i.e. bacterial meningitis (BM), viral meningitis (VM), and neuroborreliosis (NB).
Results |
Two-hundred patients (82 BM, 86 VM, and 32 NB) were included. The proportions of monocytes were higher in VM (median 8%; range 0–57%) than in BM (median 5%; range 0–60%, P=0.03) or NB (median 5%; range 0–53%, P=0.46), with a high value overlap between conditions.
Conclusion |
CSF monocytes should not be used to discriminate BM from VM and NB because of value overlaps.
Il testo completo di questo articolo è disponibile in PDF.Résumé |
Objectifs |
La présence de monocytes dans le LCS est source d’interrogation.
Patients et méthodes |
Étude des monocytes chez des patients hospitalisés pour méningite (leucorachie>10/mm3 ou >30/mm3 pour les enfants<2 mois) bactérienne (MB), virale (MV) ou neuroborréliose (NB).
Résultats |
Deux cents patients (82 BM, 86 VM et 32 NB) ont été inclus. Les monocytes étaient plus élevés dans les MV (médiane 8 % ; extrêmes 0–57 %) que dans les MB (médiane 5 %; extrêmes 0–60 %, p=0,03) ou les NB (médiane 5 % ; extrêmes 0–53 %, p=0,46), avec un chevauchement important des valeurs entre les trois groupes.
Conclusion |
La quantité de monocytes dans le LCS ne devrait pas être utilisée pour discriminer MB, MV et NB du fait d’un chevauchement important des valeurs.
Il testo completo di questo articolo è disponibile in PDF.Keywords : CSF leukocytes, CSF monocytes, Meningitis
Mots clés : Leucocytorachie, Méningite, Monocytes
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| ☆ | This work has not been published before and is not under consideration for publication elsewhere. |
Vol 48 - N° 4
P. 286-290 - Giugno 2018 Ritorno al numero
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