The advances in understanding the pathophysiology and anatomy of adipose tissue together with the emergence of technological innovations in procedures and devices for fat reduction have led to a dramatic rise in patient demand for this procedure. The objective of this continuing medical education series, which is intended for the novice or experienced dermatologist, is to provide an update of the pathophysiology and anatomic considerations of adipose tissue, and detail the liposuction procedure, from patient selection/management to the latest developments in liposuction devices. Information presented was collected from peer-reviewed literature, the latest guidelines of the American Society of Plastic Surgeons, and the authors’ personal clinical experience. The goal of these continuing medical education articles is to assist physicians in providing the best clinical care for their patients who are requesting fat reduction.