Targeting miRNAs by natural products: A new way for cancer therapy - 27/10/20
pagine | 9 |
Iconografia | 5 |
Video | 0 |
Altro | 0 |
Graphical abstract |
Highlights |
• | MiRNAs Function as Oncogenes or Tumor Suppressors. |
• | MiRNAs Function as Diagnostic and Prognostic Markers. |
• | Transcriptional and Epigenetic Regulation of MiRNAs by Natural Products. |
• | Natural Products Modulate MiRNA Processing and Maturation. |
• | Natural Products Regulate Mirna in an Indirect Way. |
Abstract |
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through mRNA degradation or translation inhibition. MiRNAs play important roles in a variety of biological processes, and dysregulation of miRNA expression is highly associated with cancer development. Individual miRNA regulates multiple gene expressions, enabling them to regulate multiple cellular signaling pathways simultaneously. Hence, miRNAs could be served as cancer biomarkers for diagnosis and prognosis, and also therapeutic targets. Recently, more and more evidences showed that natural products such as paclitaxel, curcumin, resveratrol, genistein or epigallocatechin-3-gallate exert their anti-proliferative and/or pro-apoptotic effects through regulating one or more miRNAs, leading to the inhibition of cancer cell growth, induction of apoptosis or enhancement of conventional cancer therapeutic efficacy. Herein, we outlined the recent advances in the regulation of miRNAs expression by the natural products and highlight the importance of these natural drugs as a potential strategy in cancer treatment. This review will help us better understand how natural products modulate miRNAs and contribute to the development of effective and safe natural drugs for therapeutic purposes.
Il testo completo di questo articolo è disponibile in PDF.Keyword : microRNAs, Natural products, Cancer therapy
Mappa
Vol 130
Articolo 110546- Ottobre 2020 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?