Moringa oleifera leaf extract enhances endothelial nitric oxide production leading to relaxation of resistance artery and lowering of arterial blood pressure - 27/10/20
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Graphical abstract |
Highlights |
• | Blood pressure-lowering effect of MOE is associated with the relaxation of the small resistance artery. |
• | The blood pressure-lowering and vasorelaxing effects induced by MOE, are partially dependent on the (eNOS) function. |
• | MOE induces the endothelium-dependent relaxation through the eNOS/sGC pathway. |
• | MOE increases NO production in human pulmonary artery endothelial cells. |
• | The vascular effect of MOE is also unrelated to prostacyclin synthesis. |
Abstract |
A mass of evidence has identified a promoting of nitric oxide (NO) production in endothelial cells using natural products as a potential strategy to prevent and treat hypertension. This study investigated whether the aqueous extract of Moringa oleifera leaves (MOE) could lower mean arterial pressure (MAP) and relax mesenteric arterial beds in rats via stimulating endothelium-derived NO production. Intravenous administration of MOE (1–30 mg/kg) caused a dose-dependent reduction in MAP in anesthetized rats. In rats pretreated with the NO-synthase inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME, 30 mg/kg, i.v.), the effect of MOE on MAP was significantly reduced. MOE (0.001–3 mg) induced relaxation in methoxamine (10 μM) pre-contracted mesenteric arterial beds, which was abolished by endothelium denudation. This endothelium-dependent vasorelaxation was reduced by L-NAME (100 μM) or the NO-sensitive guanylyl cyclase inhibitor, 1H- [1,2,4]-oxadiazolo-[4,3-a]-quinoxalin-1-one (10 μM). In primary human pulmonary artery endothelial cells, MOE (3–30 μg/mL) induced NO production, which was inhibited by L-NAME (100 μM) pretreatment. These findings show that MOE stimulates the endothelium-derived NO release for driving its vasorelaxation to lower arterial blood pressure. These suggest the development of MOE as a natural antihypertensive supplement.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : ACh, BP, COX, EC50, Emax, eNOS, HPAECs, L-NAME, MAP, MOE, MPP, MTT, NO, ODQ, Phe, PPV, SNP
Keywords : Blood pressure, Endothelium, Moringa, Nitric oxide, Vasodilator
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Vol 130
Articolo 110605- Ottobre 2020 Ritorno al numero
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