Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential - 19/03/21
, Jiaxu Chen a, ⁎ Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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Graphical abstract |
Highlights |
• | The biogenesis and functions of circular RNAs have been elaborated in this review. |
• | Circular RNAs play critical roles in the development of depression by competitively binding to certain microRNAs. |
• | Circular RNAs may be potential targets for diagnosis and treatment of depression. |
Abstract |
Depression is the second most common disease burden worldwide that threatens human health; however, mechanisms underlying the development of depression remain unclear. A family of non-coding RNAs, circular RNAs (circRNAs), has been shown to play a critical role in the development of depression by competitively binding to certain microRNAs (miRNA) and regulating the expression of target genes. Behavioral symptoms of depression may be ameliorated by knockdown or overexpression of depression-associated circRNAs. In this review, we summarized important functions of circRNAs and analyzed the most recent findings regarding the expression and biological function of circRNAs in depression. We discussed novel circRNA-based strategies to illuminate potential therapeutic targets that may aid in the development of new treatments for depression.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : circRNAs, miRNA, HPA, ncRNA, lncRNAs, ceRNA, MDD, CUS, CUMS, LPS, MS, ciRNAs, EIciRNAs, RBPs, MREs, CDR1as, 3′-UTR, ciRS-7, AKT3, CDK2, ID1, E2F1, FAK, HIFα, MBL, snRNAs, Pol Ⅱ, AD, PD, SZ, MPP, AGO, NF-κB, DLPFC, PBMCs, PFC, qRT-PCR, QSBSS, HSP90, ALKBH5, T2DM, EA, SLPNs, VMPC, CREB1, BNDF, rTMS, CNS, FMT, NLRP3 KO, PPP1R13B, ERS, FAAH
Keywords : circRNAs, miRNA sponge, circRNA function, Expression of circRNAs, Depression therapy
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Vol 137
Articolo 111244- maggio 2021 Ritorno al numero
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