Abnormal post-prandial glucagon-like peptide release in patients with Crohn's disease - 16/06/21
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
| pagine | 9 |
| Iconografia | 3 |
| Video | 0 |
| Altro | 0 |
Highlights |
• | What is already known on this subject? |
• | Glucagon-like peptide (GLP)-1 and -2 have been shown to regulate immune responses in immune-mediated disorders, such as Crohn’s disease (CD) |
• | What are the new findings? |
• | Basal GLP-1 levels were up-regulated in CD, while GLP-1 secretion was significantly reduced compared to healthy volunteers (HV) and patients with metabolic syndrome (MS) |
• | Post-prandial GLP secretion was positively correlated to insulin secretion indices, both in CD and MS |
• | How might it impact on clinical practice in the foreseeable future? |
• | Future research should focus on metabolic alterations and GLP secretion in patients with CD, as these may represent therapeutic targets |
Abstract |
Background and aims |
Glucagon-like peptide GLP-1 and -2 have been shown to regulate immune responses in immune-mediated disorders, including Crohn’s disease (CD). Our aim was to investigate post-prandial GLP release and its potential link to chronic inflammation, insulin secretion/sensitivity and body composition changes in CD patients.
Methods |
Fifteen patients with CD, 15 healthy controls (HC) and 15 patients with metabolic syndrome (MS) were recruited. All patients underwent assessment of body composition by means of bio-impedance followed by a meal tolerance test (MTT). Only one CD patient did not tolerate the MTT and was excluded.
Results |
Basal GLP-1 levels were up-regulated in CD, however, as compared to HC, stimulated GLP-1 secretion was significantly reduced in CD (-31 %, p < 0.05) as in MS (-52 %, p < 0.003). Similarly, basal GLP-2 levels were comparable to that of HC, while response to MTT in CD was virtually absent (p < 0.05). Similar fasting insulin sensitivity, estimated 1st and 2nd phase insulin secretion and insulinogenic index were found in CD and in HC. Post-prandial GLP secretion was positively correlated to insulin secretion indices, both in CD and MS. In CD, high-sensitive C reactive protein levels (hsCRP) and extra-cellular to intra-cellular water ratio (ECW/ICW), an index of cellular inflammation, were inversely correlated with stimulated GLP-1 (p < 0.05 and p < 0.01, respectively) levels.
Conclusion |
CD is characterized by abnormal fasting and post-prandial GLP levels. Circulating GLP influences subclinical inflammation and glucose metabolism in CD patients, but not their body composition parameters.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : BIA, CD, ECW:ICW, EEC, FFM, FFMI, FM, GLP, HC, hsCRP, IBD, i-FABP, IGI, IMAT, MS, MTT
Keywords : body composition, glucagon-like peptide, inflammation, insulin secretion, metabolic syndrome
Mappa
Vol 45 - N° 4
Articolo 101533- luglio 2021 Ritorno al numero
Articolo precedente
- The relationship between cardiac muscularis propria and clinical outcomes of peroral endoscopic myotomy in achalasia
- Qing-lin He, Xiu-bing Chen, Dong-hong Lu, Wei Luo, Lin Tao, Hong-jian Ning, Shao-mei Tang, Yi-ling Peng, Shan-yu Qin, Hai-xing Jiang
- Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial
- Kourosh Masnadi Shirazi, Simin Sotoudeh, Arman Masnadi Shirazi, Seyyed-Yaghoub Moaddab, Zahra Nourpanah, Zeinab Nikniaz
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?