Basic Science and Molecular Genetics of Prostate Cancer Aggressiveness - 29/06/21

Doi : 10.1016/j.ucl.2021.04.004

Matthew J. Schiewer, PhD ^a,^b,^⁎ , Karen E. Knudsen, MBA, PhD ^c,^d,^e,^f
^a Department of Urology, Urology Research Laboratory, Thomas Jefferson University, Sidney Kimmel Cancer Center, 233 South 10th Street BLSB 804, Philadelphia, PA 19107, USA
^b Department of Cancer Biology, Urology Research Laboratory, Thomas Jefferson University, Sidney Kimmel Cancer Center, 233 South 10th Street BLSB 804, Philadelphia, PA 19107, USA
^c Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA
^d Department of Urology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA
^e Department of Medical Oncology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA
^f Department of Radiation Oncology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA

^∗Corresponding author. 233 South 10th Street BLSB 804, Philadelphia, PA 19107.233 South 10th Street BLSB 804PhiladelphiaPA19107

Riassunto

Androgen receptor function, tumor cell plasticity, loss of tumor suppressors, and defects in DNA repair genes affect aggressive features of prostate cancer. Prostate cancer development, progression, and aggressive behavior are often attributable to function of the androgen receptor. Tumor cell plasticity, neuroendocrine features, and loss of tumor suppressors lend aggressive behavior to prostate cancer cells. DNA repair defects have ramifications for prostate cancer cell behavior.

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Keywords : Prostate cancer, Androgen receptor, Cellular plasticity, NEPC, DNA repair

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Key points

Introduction

Germline alterations associated with prostate cancer aggressiveness

Androgen receptor pathway

Loss of key tumor suppressors

Tumor cell plasticity

DNA repair pathways

Summary

Esportazione

Vol 48 - N° 3

P. 339-347 - agosto 2021 Ritorno al numero

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Genetic Counseling for Men with Prostate Cancer
Colette Hyatt, Carey McDougall, Susan Miller-Samuel, Jessica Russo

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Genetic Contribution to Metastatic Prostate Cancer
Alexandra O. Sokolova, Elias I. Obeid, Heather H. Cheng

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Basic Science and Molecular Genetics of Prostate Cancer Aggressiveness - 29/06/21

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