Cardiac arrhythmias and electrophysiologic responses during spontaneous hyperglycaemia in adults with type 1 diabetes mellitus - 02/11/21
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.
Si connetta per beneficiarne
Highlights |
• | Spontaneous hyperglycaemia didn’t prolong QTc interval in people with T1DM and without history of cardiovascular disease. |
• | Cardiac arrhythmias were uncommon and confined to bradycardia and ectopic beats. |
• | There was considerable diurnal and inter-subject variability in the incidences of arrhythmias. |
• | Reassuringly, hyperglycaemia wasn’t linked with clinically relevant arrhythmias. |
Abstract |
Aim |
We examined the effect of spontaneous hyperglycaemia in adults with type 1 diabetes mellitus (T1DM) and without history of cardiovascular disease on heart rate variability (HRV), cardiac repolarisation and incidence of cardiac arrhythmias.
Methods |
Thirty-seven individuals with T1DM (age 17–50 years, 19 males, mean duration of diabetes 19.3 SD(9.6) years) underwent 96 h of simultaneous ambulatory 12-lead Holter ECG and blinded continuous interstitial glucose (IG) monitoring (CGM). HRV, QT interval and cardiac repolarisation were assessed during hyperglycaemia (IG ≥ 15 mmol/l) and compared with matched euglycaemia (IG 5−10 mmol/l) on a different day, separately during the day and night. Rates of arrhythmias were assessed by calculating incidence rate differences.
Results |
Simultaneous ECG and CGM data were recorded for 2395 hours. During daytime hyperglycaemia vs euglycaemia the mean QTc interval duration was 404 SD(21)ms vs 407 SD(20)ms, P = 0.263. T-peak to T-end interval duration corrected for heart rate (TpTendc) shortened: 74.8 SD(16.1)ms vs 79.0 SD(14.8)ms, P = 0.033 and T-wave symmetry increased: 1.62 SD(0.33) vs 1.50 SD(0.39), P = 0.02. During night-time hyperglycaemia vs euglycaemia, the mean QTc interval duration was 401 SD(26)ms vs 404 SD(27)ms, P = 0.13 and TpTend shortened: 62.4 SD(12.0)ms vs 67.1 SD(11.8)ms, P = 0.003. The number of cardiac arrhythmias was low and confined to bradycardia and isolated ectopic beats. A considerable inter-subject and diurnal variability was observed.
Conclusions |
Hyperglycaemia in individuals with T1DM without known cardiovascular disease was not associated with clinically important cardiac arrhythmias.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Cardiac arrhythmias, Cardiac electrophysiology, Heart rate variability (HRV), Hyperglycaemia, QTc interval, Type 1 diabetes mellitus (T1DM)
Mappa
Vol 47 - N° 5
Articolo 101237- Settembre 2021 Ritorno al numero
Articolo precedente
- Liraglutide and sitagliptin have no effect on intestinal microbiota composition: A 12-week randomized placebo-controlled trial in adults with type 2 diabetes
- Mark M. Smits, Kristina S. Fluitman, Hilde Herrema, Mark Davids, Mark H.H. Kramer, Albert K. Groen, Clara Belzer, Willem M. de Vos, Djuna L. Cahen, Max Nieuwdorp, Daniël H. van Raalte
- Canagliflozin could improve the levels of renal oxygenation in newly diagnosed type 2 diabetes patients with normal renal function
- Saijun Zhou, YuLing Zhang, TongDan Wang, Shuai Huang, Siyi Gong, Junmei Wang, Pei Yu
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.