Exposure to persistent organic pollutants and the risk of type 2 diabetes: a case-cohort study - 02/11/21
, Fanny Rancière c, d, 1, Rémy Slama e, f, Ronan Roussel g, h, i, Hannu Kiviranta j, Xavier Coumoul k, Beverley Balkau l, Jérémie Botton m, nthe D.E.S.I.R. Study Group
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
Articolo gratuito.
Si connetta per beneficiarne
Highlights |
• | Exposure to 22 persistent organic pollutants was studied in 753 people |
• | These 22 included polychlorinated biphenyls and organochlorine insecticides |
• | Associations with 9-year, incident type 2 diabetes were studied |
• | None of the compounds, nor combinations, was associated with type 2 diabetes risk |
• | We found no support for the hypothesis that persistent organic pollutants are independent risk factors for diabetes |
Abstract |
Aims |
To explore exposure to 22 persistent organic pollutants (POPs) and incident type 2 diabetes in a population-based, prospective cohort.
Methods |
This case-cohort study on 753 participants without type 2 diabetes at baseline, was followed-up over nine years, as part of the French D.E.S.I.R. cohort. We measured 22 POPs in fasting serum at baseline. The associations between baseline POP concentrations, pre-adjusted for lipids, BMI, age and sex, with incident type 2 diabetes, were assessed using Prentice-weighted Cox regression models (time scale: age), adjusted for traditional confounding factors. POPs were also modelled summed in functional groups: polychlorinated biphenyls (∑PCB) and organochlorines (∑OC) and also individually, after log-transformation, in adjusted Cox models.
Results |
There were 200 incident diabetes cases over nine years. Pre-adjusted POP concentrations were not related to diabetes risk for any of the 22 POPs examined. The fully-adjusted hazard ratios (HRs) per interquartile range of the pre-adjusted POPs, ranged from 0.87 (95% CI: 0.64,1.19) to 1.22 (0.93,1.59,). For dichlorodiphenyldichloroethylene (p, p'-DDE) and dichlorodiphenyltrichloroethane (p, p'-DDT), the HRs were 1.09 (0.83,1.43) and 0.89 (0.70,1.13), respectively. The HRs for PeCB, HCB, β-HCH, γ–HCH, oxychlordane, trans-nonachlor were 0.98 (0.85,1.13), 1.06 (0.84,1.33), 1.22 (0.93,1.59), 1.13 (0.89,1.42), 1.00 (0.76,1.31), 0.86 (0.66,1.13), respectively. HRs for ∑PCB, ∑OC and for individual log-transformed POPs did not differ significantly from one.
Conclusion |
We did not observe any relations between exposure to POPs and diabetes in this population-based cohort. These results do not support causal inferences reported in previous studies linking serum POP concentrations and diabetes risk.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Diabetes mellitus, Incidence, Organic pollutants, Organochlorine insecticides, Persistent, Pesticides, Polybrominated biphenyls
Mappa
Vol 47 - N° 5
Articolo 101234- Settembre 2021 Ritorno al numero
Articolo precedente
- Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19
- Jean-Daniel Lalau, Abdallah Al-Salameh, Samy Hadjadj, Thomas Goronflot, Nicolas Wiernsperger, Matthieu Pichelin, Ingrid Allix, Coralie Amadou, Olivier Bourron, Thierry Duriez, Jean-François Gautier, Anne Dutour, Céline Gonfroy, Didier Gouet, Michael Joubert, Ingrid Julier, Etienne Larger, Lucien Marchand, Michel Marre, Laurent Meyer, Frédérique Olivier, Gaëtan Prevost, Pascale Quiniou, Christelle Raffaitin-Cardin, Ronan Roussel, Pierre-Jean Saulnier, Dominique Seret-Begue, Charles Thivolet, Camille Vatier, Rachel Desailloud, Matthieu Wargny, Pierre Gourdy, Bertrand Cariou, for the CORONADO investigators
- Significant association between blood lead (Pb) level and haemoglobin A1c in non-diabetic population
- Chien-Wei Chang, Chih-Wen Wang, Da-Wei Wu, Wen-Hsien Lee, Ying-Chih Chen, Yi-Hsueh Liu, Chiu-Hui Li, Chun-Chi Tsai, Wen-Yi Lin, Szu-Chia Chen, Chih-Hsing Hung, Chao-Hung Kuo, Ho-Ming Su
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.