Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium - 21/08/11
, Teddy D. Pan, MD c, Charles J. McDonald, MD a
Correspondence to: Leslie Robinson-Bostom, MD, Department of Dermatology, Brown Medical School, Rhode Island Hospital–APC 10, 593 Eddy St, Providence, RI 02903.Providence, Rhode Island, and Norwood, Massachusetts
Abstract |
Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of MRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki-67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of MRH.
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| Funding sources: None. Conflicts of interest: None identified. Reprints not available from the authors. |
Vol 53 - N° 6
P. 1075-1079 - dicembre 2005 Ritorno al numero
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