Hyperpigmentation in Chediak-Higashi syndrome - 29/08/11
Doi : 10.1016/S0190-9622(03)00123-3
Sultan Al-Khenaizan, MBBS, FRCPC a, ⁎ 
a Division of Dermatology, Department of Medicine, King Fahad National Guard Hospital, Riyadh, Saudi Arabia
*Correspondence to: Sultan Al-Khenaizan, MBBS, FRCP (C), Acting Consultant, Division of Dermatology, Department of Medicine, MBC 1443, King Fahad National Guard Hospital, P.O. Box 22490, Riyadh 11426, Saudi Arabia.
Abstract |
We describe a 412 -year-old Saudi Arabian boy born to consanguineous parents who was initially seen with gradual onset of fever and abdominal distention. The patient was found to have speckled hypopigmentation and hyperpigmentation of the sun-exposed areas. The finding of large cytoplasmic granules in blood and bone marrow leukocytes established the diagnosis of Chediak-Higashi syndrome. We review the literature on this finding, which might be underreported, especially in darkly pigmented races.
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 | This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology. Funding sources: None. Conflict of interest: None identified. |
© 2003
American Academy of Dermatology, Inc.. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 49 - N° 5S
P. 244-246 - novembre 2003 Ritorno al numero
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