Despite intense investigative interest over the last 3 decades relating to the proinflammatory response of severe infection, the treatment of sepsis remains targeted toward medical and surgical treatment of the infection nidus and support of organ dysfunction.<sup>12 Dellinger R.P., Opal S.M., Rotrosen D., , e al. the Future of Sepsis Research Planning Committee and Panel Members From the bench to the bedside. The future of sepsis research. Executive Summary of an American College of Chest Physicians, National Institute of Allergy and Infectious Disease, and National Heart, Lung, and Blood Institute Workshop Chest 1997 ;  111 : 744

Cliccare qui per andare alla sezione Riferimenti</sup> Therapy can be divided into immediate steps taken to stabilize the patient, followed by more definitive therapeutic intervention. Other diseases and states may mimic sepsis and need to be considered during the initial evaluation. A wide variety of organisms may be associated with sepsis. Hypotension and hypoperfusion accompany severe sepsis and septic shock and warrant intense efforts to optimize organ perfusion. Other supportive care issues, such as stress ulcer prophylaxis and nutritional support, are important adjuncts to therapy.