Syncytiotrophoblastic fragments in first-trimester decidual veins: Evidence of placental perfusion by the maternal circulation early in pregnancy - 08/09/11
Abstract |
Objective: To determine whether maternal placental perfusion occurs in the first trimester, this study compared veins in endometrium with those in decidua. We hypothesize that veins draining the placenta become dilated and contain syncytiotrophoblastic fragments. Study Design: Normal late-secretory endometrial biopsy specimens (n = 10) were compared with elective abortion decidua at 7 to 11 weeks (n = 100). Tissue sections were processed by routine staining and immunohistochemical studies. The cross sections of veins and glands were counted in 25 decidual biopsy specimens, and the number of syncytiotrophoblastic fragments in veins or glands was determined. Statistical significance by χ2 or linear regression analysis was P < .05. Results: All sets of decidua had dilated veins; no secretory endometrium did. Intravenous syncytiotrophoblastic fragments were seen in 91 of 100 sets of decidua. There were more syncytial elements in veins (572/6845, 8.4%) than in glands (13/23,310, 0.06%) (P < .001). Conclusion: Decidual veins were distended and contained syncytiotrophoblastic fragments, consistent with maternal intervillous perfusion in the first trimester. (Am J Obstet Gynecol 1999;181:455-9.)
Il testo completo di questo articolo è disponibile in PDF.Keywords : Placenta, maternal circulation, trophoblast cells, first trimester
Mappa
 | From the Department of Obstetrics and Gynecology, School of Medicine, University of Utah. |
| Supported by a Willard Eccles Charitable Trust grant to the Perinatal Genetics Laboratory and by the March of Dimes Birth Defects Foundation (grant 6-FY95-0193). Dr Ward is an Investigator in the Eccles Program in Human Molecular Biology and Genetics (Obstetrics and Gynecology Departmental Grant, University of Utah, 1995). |
 | Reprint requests: Kenneth Ward, MD, Department of Obstetrics and Gynecology, School of Medicine, University of Utah, 50 North Medical Dr, Salt Lake City, UT 84112. |
| 0002-9378/99 $8.00 + 0 6/1/98385 |
Vol 181 - N° 2
P. 455-459 - agosto 1999 Ritorno al numero
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