INFECTION- AND MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROMES : Secondary Hemophagocytic Lymphohistiocytosis - 09/09/11

Doi : 10.1016/S0889-8588(05)70521-9

Gritta Janka, MD ^a, Shinsaku Imashuku, MD ^b, Göran Elinder, MD, PhD ^c, Marion Schneider, PhD ^d, Jan-Inge Henter, MD, PhD ^e

^a Department of Hematology and Oncology, Children's University Hospital, Hamburg, Germany (GJ)

^b Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan (SI)

^c Institution of South Hospital Karolinska Institute, Sachs' Children's Hospital, Stockholm, Sweden (GE)

^d Immunology Laboratory, Institute for Hemostasis and Transfusion Medicine, Düsseldorf University, Düsseldorf, Germany (MS)

^e Child Cancer Research, Karolinska Institute, Department of Pediatric Hematology and Oncology, Karolinska Hospital, Stockholm, Sweden (J-IH)

Riassunto

A lymphohistiocytic proliferation with hemophagocytosis may develop as a result of and secondary to strong immunologic activation, such as a severe infection. The condition has been described in immunocompromised hosts in association with viral infections. Although the term virus-associated hemophagocytic syndrome (VAHS) is frequently used,^{36 Risdall R.J., McKenna R.W., Nesbit M.E. , e al. Virus-associated hemophagocytic syndrome: A benign histiocytic proliferation distinct from malignant histiocytosis Cancer 1979 ; 44 : 993 [cross-ref]

Cliccare qui per andare alla sezione Riferimenti} bacteria and parasites may induce secondary hemophagocytic lymphohistiocytosis (HLH) as well. The syndrome may also develop subsequent to other types of immunologic stress and activation, such as in association with malignancies (malignancy-associated hemophagocytic syndrome, MAHS).^{17 Henter J.-I., Elinder G., Öst Å., the FHL Study Group of the Histiocyte Society Diagnostic guidelines for hemophagocytic lymphohistiocytosis Semin Oncol 1991 ; 18 : 29

Cliccare qui per andare alla sezione Riferimenti}

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INFECTION-ASSOCIATED HEMOPHAGOCYTIC

Pediatric Cases

Triggering Organisms

Pathohistology

Immunologic Investigations

Treatment and Survival

Differential Diagnosis

Recommendations for Therapy

MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROME (MAHS)

Symptoms and Course of Disease

Pathophysiology

Differential Diagnosis

Recommendations for Therapy

Address reprint requests to Jan-Inge Henter, MD, PhD, Pediatric Hematology and Oncology, Karolinska Hospital, S-171 76 Stockholm, Sweden
This research is supported by grants from the Children's Cancer Foundation of Sweden and the Medical Research Council of Sweden.

Esportazione

Vol 12 - N° 2

P. 435-444 - aprile 1998 Ritorno al numero

Articolo precedente

FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS : Primary Hemophagocytic Lymphohistiocytosis
Jan-Inge Henter, Maurizio Aricò, Göran Elinder, Shinsaku Imashuku, Gritta Janka

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MALIGNANT HISTIOCYTOSIS : Histologic, Cytochemical, Chromosomal, and Molecular Data with a Nosologic Discussion
Jean Gogusev, Christian Nezelof

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INFECTION- AND MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROMES : Secondary Hemophagocytic Lymphohistiocytosis - 09/09/11

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