Leflunomide in dermatology - 14/03/12
Reprint requests: Alan S. Boyd, MD, 719 Thompson Ln, Suite 26300, Nashville, TN 37204.Abstract |
Leflunomide is an oral disease-modifying antirheumatic drug administered to patients with rheumatoid and psoriatic arthritis. This drug inhibits dihydroorotate dehydrogenase, an enzyme critical in the production of intracellular pyrimidines, and down-regulates tumor necrosis factor-alfa activity. Leflunomide has demonstrated usefulness in treating cutaneous psoriasis along with other dermatologic and rheumatologic conditions.
Il testo completo di questo articolo è disponibile in PDF.Key words : atopic dermatitis, dihydroorotate dehydrogenase, leflunomide, psoriasis, psoriatic arthritis, rheumatoid arthritis, tumor necrosis factor-alfa
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 66 - N° 4
P. 673-679 - aprile 2012 Ritorno al numero
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