Single High Oral Dose Amiodarone for Cardioversion of Recent Onset Atrial Fibrillation - 11/07/12
, Michael J.A. Williams, MD a, b
Corresponding author at: Cardiology Department, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand. Tel.: +64 3 474 0999; fax: +64 3 474 7655.Riassunto |
Background |
Selection of a pharmacological agent and mode of administration for cardioversion is a challenging task in recent onset atrial fibrillation.
Aim |
To report our experience using single high dose oral amiodarone for the cardioversion of recent onset atrial fibrillation to sinus rhythm in patient presenting with symptoms within 48h.
Methods |
We retrospectively studied 48 patients with recent onset symptomatic atrial fibrillation presenting to the emergency department. These patients were admitted to the cardiology ward and treated with single high oral dose (30mg/kg) amiodarone.
Results |
The mean±SD age of patients was 60.1±4.4years and 54% were male. Forty-two (90%) of them had symptoms <24h. The common risk factor for atrial fibrillation was hypertension (73%). Of 48 patients, 47 (98%) were chemically cardioverted to sinus rhythm in 6.3±0.8h. The mean pre-treatment heart rate and blood pressure were 154/min and 159.3/88.0mmHg. The lowest heart rate and blood pressure were 43/min and 122.5/80.9mmHg respectively. High dose amiodarone was overall well tolerated except in three patients having self-limited gastrointestinal symptoms. Hospital discharge occurred in less than 24h after presentation in all but one patient.
Conclusion |
Single high dose oral amiodarone is safe and highly effective for patients with recent onset atrial fibrillation eligible for acute chemical cardioversion.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Atrial fibrillation, Oral amiodarone, Chemical cardioversion
Mappa
Vol 21 - N° 8
P. 444-448 - agosto 2012 Ritorno al numero
Articolo precedente
- A Comparison of Precipitants and Mortality When Acute Decompensated Heart Failure Occurs in the Community and Hospital Settings
- D.McD. Taylor, M. Ng Tang Fui, A.R. Chung, L. Gani, J.D. Zajac, L.M. Burrell
- A Suggested Paradigm for Coronary Risk Screening in Asymptomatic Persons—Assessment of Total Coronary Atheromatous Burden
- Constantine N. Aroney
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?