Estrogen receptor expression in lumbar intervertebral disc of the elderly: Gender- and degeneration degree-related variations - 24/05/14

Doi : 10.1016/j.jbspin.2013.09.002

Xiao-xing Song ^a,^b,^{^{1
Xiao-xing Song and Zhen Guo contributed equally to this work.}}, Yong-juan Yu ^a, Xin-feng Li ^a,^⁎ , Zu-de Liu ^a, Bu-wei Yu ^b,^⁎ , Zhen Guo ^a,^{^{1
Xiao-xing Song and Zhen Guo contributed equally to this work.}}
^a Department of Orthopaedic Surgery, Ren Ji Hospital,School of Medicine, Shanghai Jiao Tong University, Shanghai, China
^b Department of Anesthesiology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

^⁎Corresponding author. Renji Hospital, 1630, Dongfang Road, Shanghai 200127, China. Tel.: +86 21 68383766; fax: +0086 21 63730455.^⁎⁎Co-corresponding author. Ruijin Hospital, 197, Ruijin Er Lu, Shanghai 200025, China. Tel.: +86 21 68383766; fax: +0086 21 63730455.

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Abstract

Objectives

Sexual dimorphism does occur in intervertebral disc (IVD) degeneration. The involvement of estrogen on IVD health has been well reported in recent years. The estrogen receptors (ER) are the main mediators of estrogen action. ER might play specific roles in the sexual variations of the IVD degeneration.

Methods

Thirty-six elderly patients with lumbar disc degeneration were selected and graded using Pfirrmann's system based on MRI images. Differences of ERα and ERβ immunoreactivity staining in nucleus pulposus of each sex and degeneration degree were recorded and compared.

Results

Both cytoplasmic and nuclear staining of ERα and ERβ immunoreactivity were observed in the nucleus pulposus cells. ERα and ERβ expression significantly decreased along with the aggravation of IVD degeneration both in males and females. Expression of ERα and ERβ protein in nucleus pulposus of males was significantly higher than that of females.

Conclusions

Gender-specific expression of ER might play a part in sexual dimorphism of IVD degeneration. Gender and degeneration condition differences should be taken into account when the effects of estrogen on IVD metabolism are studied further.

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Keywords : Intervertebral disc, Degeneration, Estrogen receptor, Nucleus pulposus

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Introduction

Methods

Patients and grading of disc degeneration

Samples harvest

Immunohistochemistry

Quantification of ERα and ERβ expression

Statistical analysis

Results

ERα and ERβ immunoreactivity in control tissues

Expression of ERα and ERβ immunoreactivity in nucleus pulposus

Degeneration degree-related expression of ERα and ERβ in nucleus pulposus

Gender-specific variations of ERα and ERβ expression in nucleus pulposus

Discussion

Disclosure of interest

Esportazione

Vol 81 - N° 3

P. 250-253 - maggio 2014 Ritorno al numero

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Estrogen receptor expression in lumbar intervertebral disc of the elderly: Gender- and degeneration degree-related variations - 24/05/14

Abstract

Objectives

Methods

Results

Conclusions

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