Sommario

• • ·Surgical Forum Opener

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• • ·Surgical Forum 2007

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• Introduction

  • ·Introduction

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    Riassunto Riassunto Mappa Mappa

• Dedication

  • ·The 58^th Volume of the Surgical Forum is Dedicated to Lazar J Greenfield, MD, FACS

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    Robert W. Thompson

     

• Surgical Forum Past Dedications

  • ·Surgical Forum Dedications

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• Excellence in Research Awards 2007

  • ·American College of Surgeons Forum on Fundamental Surgical Problems Resident/Fellow Excellence in Research Awards 2007

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• Alimentary Tract I

  • ·Role of actin cytoskeleton in deoxycholate (DC) induced gastric mucosal cell death

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    Anna M. Leung, Maria Redlak, Thomas Miller

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  • ·Does resection of pancreas cancer have a palliative effect? Longterm appraisal of readmissions

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    Irina Yermilov, Sushma Jain, Evangelos Sekeris, Clifford Ko, James Tomlinson

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  • ·Role of vagal fibers in post-transcriptional regulation of intestinal sodium-glucose cotransporter expression

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    Adam T. Stearns, Anita Balakrishnan, Jan Rounds, David Rhoads, Stanley W. Ashley, Ali Tavakkolizadeh

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  • ·Dorsal motor nucleus of the vagus (DMV): A CNS site that directly regulates activity of the lower esophageal sphincters

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    Patrick G. Jackson, Mark Niedringhaus, Rebecca Pearson, Janell Richardson, Stephen Evans, Richard Gillis, Niaz Sahibzada

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  • ·Altered gallbladder absorption/secretion in leptin-resistant obese mice

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    Kyle Yancey, Deborah Swartz-Basile, Abhishek Mathur, Debao Lu, Attila Nakeeb, Henry Pitt

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  • ·Re-operating on gastric bypass patients: High incidence of mesenteric defects

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    Sharon L. Bachman, Timothy Geiger, Peter Rippey, Archana Ramaswamy, Roger de la Torre, Stephen Scott

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  • ·Altered human small bowel contractility in obesity

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    Tom K. Gallagher, Alan W. Baird, Desmond C. Winter

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  • ·Comparison of minimally invasive vs open roux-en-y gastric bypass on immune effector cell function

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    Bryan A. Whitson, Jonathan D’Cunha, Chuong Hoang, Baolin Wu, Sayeed Ikramuddin, Henry Buchwald, Angela Panoskaltsis-Mortari, Robert Kratzke, Jeffrey Mille, Michael Maddaus

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  • ·Chemical acidification decreases peritoneal macrophage inflammatory response

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    Julia E. Grabowski, Antonio DeMaio, Mark Talamini, Virginia Vega

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  • ·Does imatinib mesylate (IM) affect longterm outcome in patients with gastrointestinal stromal tumors (GISTs)?

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    Judy Jin, Ann Robinson, Joseph Willis, Jeffrey Hardacre, Julian Kim

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  • ·Growth factors enhance neomucosal development in tissue-engineered intestine

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    Vatche G. Agopian, Beatrix Wulkersdorfer, David C. Chen, Jane Lee, Matthias Stelzner

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  • ·Effects of oxidative stress and hypoxia on intestinal wound healing and matrix metalloproteinase expression

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    Dana Hayden, Christopher Forsyth, Ali Keshavarsian, Richard Prinz

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• Alimentary Tract II

  • ·Microvascular acclimatization to hypoxia: role of iNOS

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    Alfred J. Casillan, Norberto Gonzalez, John Wood, James Thomas

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  • ·TNF-alpha enhances Il-1-beta-mediated inducible nitric oxide synthase (iNOS) release from rat intestinal epithelial cells (IEC-6)

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    Brian Lugo, Yigit Guner, Anatoly Grishin, Jeffrey Upperman, Jin Wang, Xiaoru Zhang, Patricia Boyle, Henri Ford

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  • ·Critical inflammatory role of Egr-1 in endotoxin induced ileus

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    Joachim Schmidt, Burkhard Stoffels, Savanh Chanthaphavong, Anthony Bauer

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  • ·Secular trends in laparoscopic colectomy from 2000–2004

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    Jason A. Kemp, Samuel R.G. Finlayson

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  • ·Glutamine deprivation activates the PI3K/Akt pathway in intestinal epithelial cells

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    Shawn D. Larson, Lindsey N. Jackson, Dai H. Chung, B. Mark Evers

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  • ·Synergistic activation of the intestinal SGLT1 promoter: a new role for the transcription factor GATA-5

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    Anita Balakrishnan, Adam Stearns, Stephen Krasinski, David Rhoads, Ali Tavakkolizadeh, Stanley W. Ashley

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  • ·Nkx2.2 homeodomain transcription factor is required for the development of serotonin-producing cells in the gut

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    Eric K. Nakakura, Emerick Gallego, Francis Lynn, Michael German, Yucheng Wang

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  • ·5-HT3 receptor agonist 2-methyl-5-HT mediates nonneural chloride secretion in human jejunum in vitro

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    Roberto C. Iglesias, Jarrod Day, Jessica Howell, John Kellum

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  • ·Regulation of P-glycoprotein in experimental necrotizing enterocolitis

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    Yigit S. Guner, Brian Lugo, Faisal Qureshi, Christian Ochoa, Wang Jin, Grishin Anatoly, Jeffrey S. Upperman, Henri R. Ford

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  • ·Association of demographic and treatment variables in longterm rectal cancer survival

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    William W. Hope, Amy Lincourt, Nicholas Lang, Andrew Stewart, Ronald Sing, Frederick Greene, B. Todd Heniford

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  • ·Serotonin signaling in diverticular disease

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    Meagan Costedio, Matthew Coates, Thomas Buttolph, Amy Danielson, Hagen Blaszyk, Gary Mawe, Neil Hyman

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  • ·Definitive risk factors for anastomotic leak in open elective colon resection

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    Paul N. Suding, Erin Jensen, Murray A. Abramson, Kamal Itani, Samuel E. Wilson

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• Cardiothoracic

  • ·Effects of insulin on myocardial angiogenic signaling in response to chronic ischemia in diabetes

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    Neel R. Sodha, Munir Boodhwani, Shigetosho Mieno, Jun Feng, Richard T. Clements, Shu-Hua Xu, Basel Ramlawi, Frank W. Sellke

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  • ·Therapeutic induction of heme-oxygenase-1 in the lung using a hemoglobin-based oxygen carrier

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    Ashok N. Babu, Sagar Damle, Ernest E. Moore, Li Hua Ao, Yong Song, Jeffrey L. Johnson, Anirban Banerjee, Michael Weyant, Xianzhong Meng, David A. Fullerton

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  • ·Cardiomyocyte death in ischemia-reperfusion is mediated by opening of the mitochondrial permeability transition pore: Role of oxidant stress during ischemia

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    Gabriel Loor, Jyothisri Kondalpalli, Danijela Dokic, Bhumika Sharma, Paul Mungai, Paul Schumacker

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  • ·Strain related changes in regional myocardial cyclin-dependent kinase (Cdk) inhibitor protein, p21 post-myocardial infarction in ovine model

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    Godfred K. Yankey, Teiluo Li, Ahmet Kilic, Kinjal Savai, Guangming Cheng, Aditee Satpute, Deyanira Prastein, Zhongjun Wu, Bartley Griffith

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  • ·Augmenting adoptive transfer of T-cells by inhibiting TGF-beta

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    Africa F. Wallace, Veena Kapoor, Jing Sun, Alex Workman, Leona Ling, Larry Kaiser, Steven Albelda

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  • ·Cell cycle regulator, polo-like kinase 1, promotes regression of murine left ventricular hypertrophy, and is upregulated in human myocardium after mechanical circulatory support

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    William E. Stansfield, Ruhang Tang, Nancy C. Moss, Craig H. Selzman

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  • ·Early ventricular restraint after MI: Cautionary results

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    Hiroaki Sakamoto, Hirotsugu Hamamoto, Liam Ryan, Landi Parish, Theodore Plappert, Martin St John-Sutton, Joseph Gorman, Robert Gorman

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  • ·TNF preconditioning of human mesenchymal stem cells maximizes the expression of angiogenic growth factors FGF2 and VEGF

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    Paul R. Crisostomo, Troy A. Markel, Meijing Wang, Christine Herring, Daniel R. Meldrum

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  • ·Minimally invasive esophagectomy can be performed safely in the elderly population

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    Anna R. Ibele, Anna Ibele, James Maloney, David Mahvi, Tracey L. Weigel

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  • ·Outcomes of lung cancer surgery in HIV-positive smokers: Initial findings

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    Robert A. Meguid, Craig M. Hooker, Justin A. DeAngelis, Marc Sussman, Stephen C. Yang, Malcolm V. Brock

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  • ·Minimally invasive approach to management of malignant pericardial effusion

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    Casandra A. Anderson, Hellan Minia, Carey Cullinane, Frederic Grannis

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  • ·Porcine valve as a model for age-specific human heart valve disease: Analysis of collagen turnover throughout development and aging

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    Elizabeth H. Stephens, K. Jane Grande-Allen

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• Critical Care I

  • ·Preventing CD14 gene and protein expression by in vivo siRNA treatment alters the burn injury response

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    Goro Tajima, Malcolm MacConmara, Ann McKenna, Christopher Stallwood, Adam Delisle, John Mannick, James Lederer

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  • ·High-mobility group box-1 (HMGB1) activation in hepatocytes is regulated by interferon-gamma (IFN-g) and interferon regulatory factor 1 (IRF1)

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    Geetha Jeyabalan, Jon Cardinal, John Klune, Allan Tsung, David Geller

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  • ·Ischemic acute kidney injury (AKI) induces caspase-dependent pulmonary endothelial apoptosis which contributes to AKI-associated lung injury

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    Heitham Hassoun, Mihaela Lie, Dmitry Grigoryev, Manchang Liu, Rubin Tuder, Hamid Rabb

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  • ·Induced hypothermia is associated with improved outcomes in porcine hemorrhagic shock

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    Mark E. George, Kristine Mulier, Greg Beilman

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  • ·Oxidant-induced Akt phosphorylation in murine macrophages requires generation of ceramide metabolites through sphingosine kinase

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    Patrick S. Tawadros, Zhanfei Wang, Simone Birch, Kati Szaszi, Ori D. Rotstein

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  • ·TLR4 determines macrophage polarization but not cellular infiltration in early sterile wounds

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    Alan Thomay, Jean Daley, Jonathan Reichner, Jorge Albina

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  • ·CPG treatment selectively prevents Treg-mediated suppression of adaptive immunity and improves outcome from sepsis post-injury

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    Malcolm MacConmara, Satoshi Fujimi, Ann McKenna, Peter Lapchak, Christopher Stallwood, Goro Tajima, Adam Delisle, John Mannick, James Lederer

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  • ·MD2 and CD14 mediate toll-like receptor 4 (TLR4) activation by high mobility group box 1 (HMGB1)

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    Kevin Mollen, Kevin Mollen, David Kaczorowski, Toshie Yoneyama, Raghuveer Vallabhaneni, Tina Kilgore, Meihua Bo, Michael Lotze, Timothy Billiar

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  • ·LPS modulates monocyte cell surface and genomic expression of scavenger receptors

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    Badar U. Jan, Marie Macor, Susette Coyle, Ashwini Kumar, Calvano Jacqueline, Michael Reddell, Steve Calvano, Stephen Lowry

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  • ·Role of hyaluronic acid and toll-like receptor 4 in regulation of inflammatory liver injury

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    Jane Liaw, Travis Pagliara, Krista Csontos, Sucharita Das, Sabarinathan Ramachandran, Thalachallour Mohanakumar, William C. Chapman

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  • ·Treatment for reperfusion injury reduces death and evidence of intestinal injury after hemorrhagic shock and resuscitation

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    Brian Williams, Jalil Afnan, Sean Oakes, Francis Moore

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  • ·Human vasoactive hormone adrenomedullin (AM) and human AM binding protein (AMBP-1) rescue experimental animals from hemorrhagic shock

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    Rongqian Wu, Weifeng Dong, Youxin Ji, Tianpen Cui, Juntao Yang, Mian Zhou, Steven Blau, Corrado P. Marini, Thanjavur S. Ravikumar, Ping Wang

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• Critical Care II

  • ·Heme oxygenase-1 (HO-1) mediates hepatocyte oxygen availability during hemorrhagic shock in vivo or hypoxia in vitro

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    Raghuveeer Vallabhaneni, Brian Zuckerbraun

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  • ·Differential tissue and cellular induction of heme oxygenase-1 by a hemoglobin-based oxygen carrier

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    Sagar S. Damle, Ashok Babu, Ernest E. Moore, Michael Weyant, Lihau Ao, Jeffrey L. Johnson, Xianzhong Meng, Anirban Banerjee, David A. Fullerton

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  • ·Right ventricular function is preserved during endotoxemia despite concomitant left ventricular failure

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    Troy A. Markel, Paul Crisostomo, Meijing Wang, Christine Herring, Daniel Meldrum

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  • ·Systemic hypoxia causes an increase in phagocytosis by peritoneal macrophages in a HIF-1 alpha dependent manner

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    Rahul J. Anand, Steven Gribar, Jeffrey Kohler, Maria Branca, Chhinder Sodhi, David Hackam

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  • ·Pressor-dependent regional tissue oxygenation changes after polytrauma

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    Michael Dudkiewicz, Kenneth Proctor

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  • ·Protein disulfide isomerase induces endothelial cell dysfunction

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    Danielle B. Peterson, Deron Jones, Jing-Song Ou, John Densmore, Sushma Kaul, Isaac Matus, Andrew Greene, David Gourlay, Kirkwood Pritchard, Tara Sander, Keith Oldham

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  • ·Urocortin1 governs microvascular fluid leak during inflammation

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    Alexander Q. Ereso, Jen Chang, Brian Curran, Julia J. Hoy, Alden Harken, Aditi Bhargava, Gregory P. Victorino

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  • ·Is irreversible shock truly irreversible?

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    Christian Shults, Zheng Chen, Elizabeth Sailhamer, Peter Rhee, Konstantinos Spaniolas, George Velmahos, Marc de Moya, Hasan B. Alam

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  • ·Damage control hematology: Impact of a trauma exsanguination protocol on survival and blood product utilization

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    Brigham K. Au, Oliver Gunter, James Isbell, Bryan Cotton

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  • ·Surviving blood loss without fluid resuscitation

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    Christian Shults, Elizabeth Sailhamer, Yongqing Li, Baoling Liu, Konstantinos Spaniolas, Malek Tabbara, Elena Koustova, Muhammad Butt, George Velmahos, Marc de Moya, Hasan B. Alam

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  • ·Erythrocytes contain a membrane lysophosphatidic acid acyltransferase that modulates serum lysophosphatidic acid concentration

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    Michael W. Cripps, Eric Soupene, Alden Harken, Frans Kuypers

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  • ·Apolipoprotein E (apoE) facilitates lipid antigen presentation during sepsis

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    Erica Lee Elford, Omar Kattan, Behzad Kasravi, Hobart Harris

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  • ·Epinephrine regulation of pro-inflammatory and anti-inflammatory macrophage cytokine expression

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    Ryan K. Engdahl, Kay Opperman, Smitha Yerrum, Alex Monroy, John Daly

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  • ·Measurement of cerebral edema using an impedance analyzer circuit

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    Matthew Harting, Carter Smith, Ravi Radhakrishnan, Pramod Dash, Brijesh Gill, Charles Cox

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• Genetic Determinants

  • ·Restoration of Smad4 expression in colon cancer cells enables autocrine bone morphogenetic protein (BMP) tumor suppressor function

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    J. Joshua Smith, Sheng-Ru Shiou, Punita Dhawan, Christian Kis, Cindy Kanies, Bonnie LaFleur, Mark de Caestecker, R. Daniel Beauchamp

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  • ·Heterogeneity of colorectal cancer: Microsatellite stability and CpG island methylator status defines distinct molecular and phenotypic populations

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    Julian A. Sanchez, Matthew Kalady, Lisa Krumroy, Alona Merkulova, Jeffrey Hammel, James Church, Graham Casey

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  • ·GDF-15 mediates the anti-tumorigenic effects of NSAIDs in intestinal cancers

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    Juan C. Gutierrez, Leonidas Koniaris, Xiaoling Jin, Teresa Zimmers

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  • ·Molecular characterization of pathologically indeterminate thyroid tumors

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    Nimmi Arora, Baixin Zhu, Theresa Scognamiglio, Thomas J. Fahey

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  • ·IRAK-1 haplotype influences cytokine response to endotoxin

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    Sherene Shalhub, Chris Junker, Sandra Jelacic, Grant O’Keefe

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  • ·Familial risk in gallbladder cancer

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    Heidi H. Jackson, Robert E. Glasgow, Sean J. Mulvihill, Lisa A. Cannon-Albright

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  • ·Dural cells with FGFR2 mutations promote osteogenic differentiation

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    Brian U. Ang, Rebecca Horn, Ryan Spivak, Hyun-Duck Nah, Richard Kirschner

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  • ·VEGF and interleukin gene haplotypes and prostate cancer among Caucasians

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    Murali K. Ankem, Krishna Yanamandra, Dawn Napper, Peter Boggs, Glenn Mills, Joseph Bocchini, Ramasubbareddy Dhanireddy

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  • ·Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: Fatty acid binding protein-7 (brain type)

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    Amy Wagner, Amber Stumbaugh, Zachary Tigue, Edmondson Jess, Agnes Paquet, Diana Farmer, Samuel Hawgood

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• Geriatric Surgery

  • ·An evaluation of the quality of care for elderly patients undergoing major abdominal surgery

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    Marcia L. McGory, Paul Shekelle, Arlene Fink, Michael Leonardi, Janak Parikh, Clifford Ko

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  • ·Infection incidence and outcomes in the surgical intensive care unit among elderly patients

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    Brian R. Swenson, Kimberley Popovsky, Traci Hedrick, Judy Jenkins, Shannon McElearney, Heather Evans, Robert Smith, Timothy Pruett, Addison May, Robert Sawyer

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  • ·High price of endocrine surgery in octogenarians

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    Heather Yeo, Pritesh Mehta, Leon Boudourakis, Tracy Wang, Sanziana Roman, Julie Ann Sosa

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  • ·Endothelial nitric oxide synthase (eNOS) mediates aneurysm formation in aged mice

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    Jose M. Pimiento, Stephen Maloney, Paul Tang, Akihito Muto, Tamara Fitzgerald, Tiffany Fancher, Stanley Dudrick, George Tellides, Alan Dardik

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  • ·Hypoxia-inducible factor-1 alpha deficiency correlates with impaired dermal wound healing in older diabetic mice

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    Lixin Liu, Xianjie Zhang, Guy Marti, Parsa Mohebi, Sherwin Brown, Huafeng Zhang, Lindsey Savino, Tomoharu Miyashita, Gregg Semenza, John Harmon

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  • ·Do the elderly benefit from identifying 12 lymph nodes for colon cancer?

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    Karl Bilimoria, Andrew Stewart, David Bentrem, Bryan Palis, Mark Talamonti, Clifford Ko

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  • ·Should we offer lung transplantation to patients over 60 years of age? An analysis of the UNOS database

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    Eric Weiss, Lois Nwakanma, Ashish Shah

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  • ·Equivalent outcomes of living donor renal transplantation in the geriatric population

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    Rolf N. Barth, John Rabets, Matthew Cooper, Luis Campos, Eugene Schweitzer, Stephen Bartlett, Benjamin Philosophe

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  • ·Inpatient complications after common major surgery in the elderly

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    Michael J. Leonardi, Sushma Jain, Janak Parikh, Marcia McGory, David Zingmond, Clifford Ko

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  • ·An assessment of the integration of geriatric issues into the general surgery curriculum

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    Hugh L. Willcox, Richard M. Bell

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  • ·Impedance cardiography: A non-invasive, perioperative strategy to alert surgeons to significant cardiovascular diseases in geriatric patients

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    Christopher L. Stout, Jonathan A. Whitten, Robert L. Vogel, Kristen B. Cave, Audra L. Morabito, Ben S. Thomas, Ralph C. Griffin, Martin L. Dalton, Joseph M. Van De Wat

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  • ·Sophorolipid treatment decreases LPS induced inflammatory responses and NO production in macrophages

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    Sophia L. Fu, Cathy Mueller, Yin-Yao Lin, Domenico Viterbo, Joelle Pierre, Vishal Shah, Richard Gross, Robert Schulze, Michael Zenilman, Martin Bluth

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• Orthopaedic Surgery

  • ·Del1 protects chondrocytes from apoptosis

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    Zhen Wang, Xingju Nie, Michael T. Longaker, George P. Yang

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  • ·Degree of fracture-associated soft-tissue injury modifies systemic inflammation and remote organ dysfunction after bilateral femur fracture

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    Philipp Kobbe, David Kaczorowski, Kevin Mollen, Timothy Billiar, Hans-Christoph Pape

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  • ·Functional and proteomic analysis of cerebrospinal fluid derived from patients with and without traumatic brain injury

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    Dieter Cadosch, Matthew Thyer, P. Frey Soenke, Günter Lochnit, Luis Filgueria, René Zellweger

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  • ·What is the role of bone-matrix and bone-marrow released in soft-tissue injury following fractures in the induction of systemic inflammation and remote organ damage?

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    Philipp Kobbe, David Kaczorowski, Kevin Mollen, Timothy Billiar, Hans-Christoph Pape

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  • ·Failure mechanisms in total hip resurfacing—results with the ASR (DePuy) prosthesis

    Pagina :S46

    Michael Klein, Bernhard Scherger, Bernd Hinkenjann, Peter Ostermann

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  • ·Morbidity and mortality after operative treatment in patients with femoral neck fractures

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    Michael Klein, Tobias Plenge, Bernhard Scherger, Bernd Hinkenjann, Peter Ostermann

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• Pediatric Surgery

  • ·Wnt5a knockout mice exhibit anorectal malformation

    Pagina :S48

    Cindy C. Tai, Frederic Sala, Henri Ford, Kasper Wang, Saverio Bellusci

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  • ·Enterobacter sakazakii induces necrotizing enterocolitis (NEC) in vivo by upregulating enterocyte IL-6 production

    Pagina :S48

    Catherine J. Hunter, Vijay K. Singamsetty, Victoria Camerini, Jeffrey S. Upperman, Nemani V. Prasadarao, Henri R. Ford

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  • ·Lack of immune response to transgene-encoded protein after in-utero gene therapy

    Pagina :S48

    Gerald S. Lipshutz, Supriya Patel, Adrienne Dow, Ronald Busuttil

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  • ·First report of a novel and phenotypically distinct stem cell population: Neonatal stem cells

    Pagina :S49

    Troy A. Markel, Paul Crisostomo, Meijing Wang, Christine Herring, Daniel Meldrum

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  • ·Laparoscopic adjustable gastric banding in obese adolescents results in android fat loss and resolution of co-morbid conditions

    Pagina :S49

    Shivani Reddy, Valerie Peck, Christine Ren, George Fielding, Evan P. Nadler

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  • ·A novel therapeutic agent in the management of inflammatory bowel disease

    Pagina :S49

    Edward Y. Yoo, Duane Duke, Marian Haber, Marshall Z. Schwartz

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  • ·Immunomodulatory DNA promotes enterocyte survival by reducing caspase-3 mediated apoptosis in the pathogenesis of necrotizing enterocolitis

    Pagina :S50

    Steven C. Gribar, Rahul Anand, Cynthia Leaphart, Chhinder Sodhi, Selma Cetin, Jun Li, Jeffrey Kohler, Maria Branca, Theresa Dubowski, David Hackam

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  • ·Toll like receptor 4 interaction with the intracellular signaling molecule, focal adhesion kinase regulates intestinal restitution in the pathogenesis of necrotizing enterocolitis

    Pagina :S50

    Cynthia L. Leaphart, Selma Cetin, Jun Li, Theresa Dubowski, David Hackam

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  • ·Continuous interferon-beta sensitizes rhabdomyosarcoma xenografts to ionizing radiation

    Pagina :S50

    Thomas L. Sims, Mackenzie McGee, J. Blair Hamner, Cathy Ng, Beth McCarville, M. Waleed Gaber, Andrew Davidoff

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  • ·Specific tyrosine residues of Ve-Cad mediate endothelial cell migration: A role in angiogenesis

    Pagina :S51

    Ian C. Mitchell, Zijuan Liu, Christine Ingle, Dorit Nahari, Lance Terada, Fiemu Nwariaku

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  • ·Activation of mitochondrial apoptotic signaling during oxidative stress in intestinal epithelial cells

    Pagina :S51

    Naira Baregamian, Jun Song, B. Mark Evers, Dai H. Chung

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  • ·Platelet derived growth factor beta (PGFR-B), is required for pericyte recruitment and angiogenesis in fibrosarcoma

    Pagina :S52

    Yong Xin Wang, Deendayal Mandal, Andrea Hayes-Jordan

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• Plastic Surgery I

  • ·Abnormal primary tissue collagen composition in recurrent incisional hernia patients

    Pagina :S53

    Brent C. White, Charles Osier, Nana Gletsu, Mercedeh Baghai, Melanie Sherman, C. Daniel Smith, Bruce Ramshaw, Edward Lin

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  • ·bFGF gene transfer by adeno-associated viral 2 vectors decreases work of active digital flexion and adhesion formation: An in vivo study up to end tendon healing stage

    Pagina :S53

    Jin Bo Tang, Yi Cao, Bei Zhu, Ke-Qin Xin, Xiao Tian Wang, Paul Y. Liu

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  • ·Biological and biomechanical assessment of a long-term bioresorbable silk-derived surgical mesh in an abdominal body wall defect model

    Pagina :S53

    Gregory H. Altman, Rebecca L. Horan, Diah S. Bramono, Quincey Simmons, Jingsong Chen, Enrico Mortarino, Heather E. Boepple, Ivan Toponarski, Adam L. Collette, Jason S. Prudom

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  • ·CD1d-restricted NKT cells regulate the inflammatory phase of cutaneous wound healing

    Pagina :S54

    David F. Schneider, Julia M. Tulley, Jessica L. Palmer, Richard L. Gamelli, Douglas E. Faunce

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  • ·Comparative healing of surgical incisions created by a standard bovie, PEAK electrosurgical cutting tool, and standard scalpel blade

    Pagina :S54

    Shang A. Loh, Grace A. Carlson, Eric Huang, Keith L. Duncan, Geoffrey C. Gurtner

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  • ·Effect of human beta-defensin-3 expression in a novel infected diabetic porcine wound model

    Pagina :S54

    Tobias Hirsch, Malte Spielmann, Baraa Zuhaili, Magdalena Fossum, Hans-Ulrich Steinau, Feng Yao, Andrew B. Onderdonk, Lars Steinstraesser, Elof Eriksson

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  • ·Gene transfer of insulin-like growth factor (IGF-1) improves wound healing in diabetic full-thickness porcine wounds

    Pagina :S55

    Baraa Zuhaili, Tobias Hirsch, Malte Spielmann, Oliver Bleiziffer, Patrik Velander, Magdalena Fossum, Lars Steinstraesser, Feng Yao, Elof Eriksson

    Mappa Mappa
  • ·Hyaluronate-iodine (hyiodine) complex in the treatment of non-healing wounds

    Pagina :S55

    Michael S. Ajemian, Shady Macaron, Robert Brenes

    Mappa Mappa
  • ·Influence of material components on cellular proliferation and vascualrity of microdformational wound therapy (MDWT)

    Pagina :S55

    Sandra S. Scherer, Giorgio Pietramaggiori, Jasmine Mathews, Anke Assmann, Dennis Orgill

    Mappa Mappa
  • ·Mortality reduction in the treatment of deep sternal wound infection after cardiac surgery

    Pagina :S56

    Evan Matros, Lauren Bayer, Jennifer Neuwalder, Sary Aranki, Lawrence Cohn, Dennis Orgill

    Mappa Mappa
  • ·Oxidative stress and hypoxia inducible factor-1 alpha regulation

    Pagina :S56

    Edward I. Chang, Eric I. Chang, Shang A. Loh, Michael G. Galvez, Geoffrey C. Gurtner

    Mappa Mappa
  • ·Regulation of the unfolded protein response in keloid fibroblasts

    Pagina :S56

    Paris D. Butler, Zhen Wang, Albert Koong, Michael T. Longaker, George P. Yang

    Mappa Mappa
  • ·Sphingosine-1-phosphate partially abrogates TGF-beta-induced aSMA expression in embryonic fibroblasts independent of the type-1 TGF-beta receptor: Implications for wound healing

    Pagina :S57

    Stephanie R. Goldberg, Virginia Sykes, Tomasz Kordula, David Lanning

    Mappa Mappa
  • ·Use of organotypic skin culture to study keloid biology

    Pagina :S57

    Paris D. Butler, Daphne Ly, Zhen Wang, Michael T. Longaker, George P. Yang

    Mappa Mappa

• Plastic Surgery II

  • ·Autologous breast reconstruction: Vanderbilt experience 1998-2005, independent predictors of displeasing outcomes

    Pagina :S58

    Joseph A. Greco, Eric Castaldo, Evelyn Wu, Rafe Donahue, Lillian Nanney, J. Jason Wendel, Kevin Hagan, R. Bruce Shack

    Mappa Mappa
  • ·Chronobiology of glucose diurnal variation in critical injury re-established after disruption because of changes in time zone

    Pagina :S58

    Heather F. Pidcoke, Sandra M. Wanek, Jose Salinas, John B. Holcomb, Steven E. Wolf, Charles E. Wade

    Mappa Mappa
  • ·Comparing FK-506 with basic fibroblast growth factor (b-FGF) on the repair of a peripheral nerve defect using an autogenous vein bridge model

    Pagina :S58

    Kongkrit Chaiyasate, Ian Jackson, Vijay Mittal

    Mappa Mappa
  • ·Differential expression of sclerostin in the calvaria of young and adult mice

    Pagina :S59

    Matthew D. Kwan, Bethany Slater, Gupta Deepak, Derrick Wan, Michael T. Longaker

    Mappa Mappa
  • ·Donor dendritic cells accelerate rejection for composite tissue allotransplantation

    Pagina :S59

    Justin M. Sacks, Ryosuke Ikeguchi, Elaine Horibe, Jignesh Unadkat, Doug Marsteller, Maryam Feili-Hariri, W.P. Andrew Lee

    Mappa Mappa
  • ·Ex vivo model of cranial suture fate

    Pagina :S59

    Bethany J. Slater, Kelly Lenton, Michael T. Longaker

    Mappa Mappa
  • ·Geometric morphometric analysis of craniofacial deformity in the noggin mutant

    Pagina :S60

    Deepak M. Gupta, Nathan M. Young, Derrick C. Wan, Lisa J. Brunet, Richard M. Harland, Jill A. Helms, Michael T. Longaker

    Mappa Mappa
  • ·Improvement of survival of ischemic flaps by AAV2-mediated bFGF gene therapy

    Pagina :S60

    Paul Y. Liu, Xiao Tian Wang, Chuanhao Chen, Jin Bo Tang

    Mappa Mappa
  • ·Non muscle myosin II regulates contractile phenotypes

    Pagina :S60

    Howard Levinson, Blaine Mischen, Bruce Klitzman, Detlev Erdmann, L. Scott Levin

    Mappa Mappa
  • ·Prospective analysis of longterm psychosocial outcomes in breast reconstruction: Two-year postoperative results from the Michigan breast reconstruction outcomes study

    Pagina :S61

    Dunya M. Atisha, Amy K. Alderman, Latoya E. Kuhn, Jennifer Davis, Julie C. Lowery, Edwin G. Wilkins

    Mappa Mappa
  • ·Surgical pitfalls in the era of minimally invasive parathyroidectomy

    Pagina :S61

    Dale Han, Robert Roses, Giorgos Karakousis, Rache Rapaport Kelz, Deepika Neemani, Jagajaran Karmacharya, Douglas Fraker

    Mappa Mappa
  • ·Impact of increasing BMI on women’s satisfaction with breast reconstruction

    Pagina :S62

    Dunya M. Atisha, Amy Alderman, Latoya Kuhn, Edwin Wilkins

    Mappa Mappa

• Progenitor Cells

  • ·Discovery of pluripotent and totipotent stem cells in the heart of the adult rat

    Pagina :S63

    Christopher L. Stout, Joshua McKenzie, Gypsy Long, Nicholas Henson, Kristina C. Hawkins, Dennis W. Ashley, Julie Collins, Douglas Hixson, Asa C. Black, Henry E. Young

    Mappa Mappa
  • ·Identification of isl-1+ cardiac progenitor cells in miniature swine

    Pagina :S63

    Andrew J. Meltzer, Stuart Houser, Matthew Weiss, Choo Ng, Jessica Sayre, Meghan Cochrane, James Allan, Joren Madsen, Bruce Rosengard, David Sachs

    Mappa Mappa
  • ·Circulating endothelial progenitor cells as a potential biomarker of gastrointestinal cancer neovascularization

    Pagina :S63

    M. Shirin Sabbaghian, Gary Rothberger, Jean-Pierre Gagner, Ross Basch, Peter Shamamian

    Mappa Mappa
  • ·Endothelial cell interactions with hepatic progenitor cells affect proliferation and differentiation

    Pagina :S64

    Maggie H. Walkup, Natasha Wright, Lisa Samuelson, David A. Gerber

    Mappa Mappa
  • ·Ischemia-induced mobilization of bone marrow resident mesenchymal stem cells is impaired in diabetes

    Pagina :S64

    Hariharan Thangarajah, Edwin Chang, Geoffrey C. Gurtner

    Mappa Mappa
  • ·Stem cells engineered to overexpress interleukin 18 binding protein (IL-18-BP) demonstrate maximum growth factor production by MAPK dependent mechanisms

    Pagina :S64

    Meijing Wang, Kirstan Meldrum, Paul Crisostomo, Troy Markel, Christine Herring, Charles Dinarello, Keith Lillemoe, Daniel Meldrum

    Mappa Mappa
  • ·Transcriptional profiling of human amniotic fluid derived stem cells and their multilineage differentiation

    Pagina :S65

    Jennifer Hipp, Bryan Tillman, Jason Hipp, Steve Hodges, Anthony Atala, Shay Soker

    Mappa Mappa
  • ·In vitro expansion of embryonic stem cells for progenitor isolation as a source of cells for tissue regeneration

    Pagina :S65

    Paul J. Kokorowski, Laura Perin, Federico Tozzi, Casey Brewer, Sargis Sedrakyan, Stefano Da Sacco, Roger DeFilippo

    Mappa Mappa
  • ·Transplantation of neural crest progenitor cells for Hirschsprung’s disease

    Pagina :S65

    Hong Qin, James Dunn

    Mappa Mappa
  • ·Novel etiology of infantile hemangioma

    Pagina :S65

    Chia J. Chung, Susan Fisher, Matthew Gormley, William Hoffman, David M. Young, Scott Hansen

    Mappa Mappa
  • ·Evidence for canonical beta-catenin signaling in neuroblastomas

    Pagina :S66

    Saif A. Ghole, Unsal Kuscuoglu, Min Hu, Yeon Jun Jeong, Karl G. Sylvester

    Mappa Mappa
  • ·Mobilization of autologous hematopoietic stem cells by targeting the CXCR4-SDF-1a axis to modulate diabetic wound healing

    Pagina :S66

    Giorgio Pietramaggiori, Paolo Fiorina, Saja Scherer, Jasimine Mathews, Mollie Jurewicz, Hans-Gunther Zwerves, Reza Abdi, Amy J. Wagers, Dennis P. Orgill

    Mappa Mappa

• Quality, Outcomes, and Costs I

  • ·Expedited treatment of lower extremity gunshot wounds

    Pagina :S67

    Javid Sadjadi, Kelley Bullard, Patrick Twomey, Terrence Liu, Alden Harken, Greg Victorino

    Mappa Mappa
  • ·Methamphetamine use by trauma patients: Current trends and consequences

    Pagina :S67

    Jessica Deree, Dale Fortlage, Vishal Bansal, Jeanne Lee, Bruce Potenza, Raul Coimbra

    Mappa Mappa
  • ·High velocity penetrating wounds to the neck: Lessons learned from the battlefields in Afghanistan and Iraq

    Pagina :S67

    Ian R. Driscoll, Paul F. Hwang, Michael M. Fuenfer, Craig D. Shriver, Alexander Stojadinovic, Jayson D. Aydelotte

    Mappa Mappa
  • ·Minority and under-insured patients experience worse survival after moderate to severe trauma: An analysis of the National Trauma Databank

    Pagina :S68

    Adil H. Haider, David Chang, David Efron, Elliott Haut, Neal Handly, Edward Cornwell

    Mappa Mappa
  • ·Hazards of benchmarking complication rates with the National Trauma Data Bank: Numerators in search of denominators

    Pagina :S68

    Shahrzad Kardooni, Elliott R. Haut, Charles A. Pierce, David Chang, David T. Efron, Adil Haider, Edward E. Cornwell

    Mappa Mappa
  • ·Comparing complications among different clinical paradigms: Trauma centers versus non-trauma centers

    Pagina :S68

    Darwin Ang, Frederick P. Rivara, Avery Nathens, Gregory J. Jurkovich, Ronald V. Maier, Jin Wang, Ellen J. MacKenzie

    Mappa Mappa
  • ·A blinded randomised controlled trial comparing porcine dermal collagen with polypropylene for primary inguinal hernia repair

    Pagina :S69

    Dan M. Ridgway, Faisal Mahmood, Lorraine Moore, Diane Bramley, Steven Stojkovic, Ahmed Al-Muhktar, Peter Moore

    Mappa Mappa
  • ·Longterm outcomes following dermal matrix used as a fascial bridge

    Pagina :S69

    William L. Newcomb, William W. Hope, Thomas M. Schmelzer, H. James Norton, Amy E. Lincourt, Gamal Mostafa, David A. Iannitti, B. Todd Heniford

    Mappa Mappa
  • ·Assessing the effects of hospital case volume on outcomes in colorectal cancer

    Pagina :S69

    William W. Hope, Thomas Schmelzer, William Newcomb, Nicholas Lang, Andrew Stewart, Amy Lincourt, Ronald Sing, Frederick Greene, B. Todd Heniford

    Mappa Mappa
  • ·Understanding the impact of reconstruction on quality of life during the breast cancer survivorship period

    Pagina :S70

    Emily Hu, Andrea Pusic, Jennifer Waljee, Latoya Kuhn, Edwin Wilkins, Amy Alderman

    Mappa Mappa
  • ·Does reoperation following lumpectomy influence patient-perceived aesthetic outcomes among women with breast cancer?

    Pagina :S70

    Jennifer F. Waljee, Emily Hu, Lisa A. Newman, Amy K. Alderman

    Mappa Mappa
  • ·Cost-effectiveness of laparoscopy versus laparotomy for initial surgical evaluation and treatment of potentially resectable hepatic colorectal metastases: A decision analysis

    Pagina :S70

    Shelly T. Karuna, Richard Thirlby, Thomas Biehl

    Mappa Mappa

• Quality, Outcomes, and Costs II

  • ·Potential pitfalls associated with using a cut-point of 12 lymph nodes as a quality of care measure for patients with NO adenocarcinoma of the colon

    Pagina :S72

    Mark B. Slidell, Nita Ahuja, Rebecca Evangelista, John White, Stephen Evans, Peter Kreishman, David Chang

    Mappa Mappa
  • ·Developing a tool to standardize operative room time benchmarks: Another way to improve surgical care

    Pagina :S72

    Andrew C. Freel, Karl Bilimoria, Florence Turrentine, Virginia Simpson, Clifford Ko, R. Scott Jones

    Mappa Mappa
  • ·Identifying patterns of adverse events: A novel system to improve surgical patient safety

    Pagina :S72

    Karl Bilimoria, Thomas Kmiecik, Debra DaRosa, Richard Bell, Nathaniel Soper, Jeffrey Wayne

    Mappa Mappa
  • ·A prospective study of the OR counting protocol

    Pagina :S73

    Caprice C. Greenberg, Rafael Diaz-Flores, Stuart Lipsitz, Scott Regenbogen, Lynn Mulholland, Francine Mearn, Shilpa Rao, Tamara Toidze, Atul Gawande

    Mappa Mappa
  • ·Does performance matter? Role of intraoperative factors versus preoperative risk in surgical outcomes

    Pagina :S73

    Scott E. Regenbogen, R. Todd Lancaster, Stuart R. Lipsitz, Caprice C. Greenberg, Matthew M. Hutter, Atul A. Gawande

    Mappa Mappa
  • ·Prediction of morbidity in high-acuity surgery: Influence of surgical performance on baseline physiology

    Pagina :S74

    Wande B. Pratt, Mark Callery, Charles Vollmer

    Mappa Mappa
  • ·Effects of volume-based referral initiatives on the delivery of high-risk surgery in the US

    Pagina :S75

    Jonathan F. Finks, Hong Ji, Onur Baser, John D. Birkmeyer

    Mappa Mappa
  • ·Trends in high surgical volume hospitals: Are the rich getting richer?

    Pagina :S75

    Peter Schilling, Joseph Galanko, John Morton

    Mappa Mappa
  • ·Elective patient care responsibilities of referral-based general surgeons result in delays in the care of emergency patients

    Pagina :S75

    John E. Scarborough, Mayur Patel, Kyla Bennett, Mark Shapiro, Kirk Ludwig, Paul Kuo, Danny Jacobs, Steven Vaslef

    Mappa Mappa
  • ·State of rural general surgery programs: A national survey of rural hospital administrators

    Pagina :S76

    Nathaniel Rieb, Brit Doty, Steven Heneghan, Randall Zuckerman

    Mappa Mappa
  • ·Longterm complications of hand assisted and standard laparoscopic surgery for diseases of the colon and rectum

    Pagina :S76

    S. Pandey, T. Sonoda, K. Trencheva, S. Lee, J.W. Milsom

    Mappa Mappa
  • ·Wiki-Surgery? Internal validity of Wikipedia as a medical and surgical reference

    Pagina :S76

    Lara Devgan, Neil Powe, Brittony Blakey, Martin Makary

    Mappa Mappa

• Quality, Outcomes, and Costs III

  • ·Effect of the number of lymph nodes sampled on postoperative survival of node-negative esophageal cancer

    Pagina :S78

    Alexander J. Greenstein, Virginia R. Litle, Scott J. Swanson, Celia M. Divino, Stuart Packer, Juan P. Wisnivesky

    Mappa Mappa
  • ·Long-term survival after colon cancer surgery: variation associated with choice of anesthesia

    Pagina :S78

    Rose Christopherson, Kenneth James, Mara Tableman, Prudence Marshall, Frank Johnson

    Mappa Mappa
  • ·Operative mortality after hepatic resection: Are literature-based rates broadly applicable?

    Pagina :S78

    Bolanle Asiyanbola, David Chang, Ana Gleisner, Hari Nathan, Martin Makary, Richard Schulick, Michael Choti, Timothy Pawlik

    Mappa Mappa
  • ·Patient satisfaction with breast reconstruction during the longterm survivorship period

    Pagina :S79

    Emily Hu, Andrea Pusic, Jennifer Waljee, Latoya Kuhn, Edwin Wilkins, Amy Alderman

    Mappa Mappa
  • ·Rural vs urban colorectal and lung cancer patients: Differences in stage at presentation

    Pagina :S79

    Ian M. Paquette, Samuel Finlayson

    Mappa Mappa
  • ·Race and insurance status predict presentation but not outcomes in perforated appendicitis in children

    Pagina :S79

    Meghan A. Arnold, David C. Chang, Paul M. Colombani, Fizan Abdullah

    Mappa Mappa
  • ·Racial disparity in surgical mortality after major hepatectomy

    Pagina :S80

    Hari Nathan, Ana Gleisner, Michael Choti, Richard Schulick, Timothy Pawlik

    Mappa Mappa
  • ·Outcomes comparison between laparoscopic and open colectomy from 2000–2004

    Pagina :S80

    Jason A. Kemp, Samuel R.G. Finlayson

    Mappa Mappa
  • ·Outpatient cholecystectomy at hospitals vs freestanding surgery centers

    Pagina :S81

    Ian M. Paquette, Douglas Smink, Samuel Finlayson

    Mappa Mappa
  • ·Prospective trial of stapled hemorrhoidopexy versus transanal hemorrhoidal dearterialization

    Pagina :S81

    Piero Nastro, Ahmed Shafi, Giordano Pasquale

    Mappa Mappa
  • ·Relative safety of pancreatic resection for chronic pancreatitis

    Pagina :S81

    Joshua S. Hill, James McPhee, Giles Whalen, Mary Sullivan, Andrew Warshaw, Jennifer Tseng

    Mappa Mappa
  • ·Open versus endovascular treatment of complex femoropopliteal occlusive disease

    Pagina :S82

    Dorian J. deFreitas, Mark L. Manwaring, Clark M. Kardys, Ricardo M. Mendoza, David W. Hudson, Taft L. Stallings, Frank Parker, William M. Bogey, Charles S. Powell, Michael C. Stoner

    Mappa Mappa

• Surgical Education

  • ·Pre-training on Southwestern stations decreases training time and cost for proficiency-based Fundamentals of Laparoscopic Surgery (FLS) training

    Pagina :S83

    Mouza T. Goova, Lisa A. Hollett, Jarrod Dale, Daniel J. Scott

    Mappa Mappa
  • ·Prospective, randomized, double-blind trial of curriculum-based training for intracorporeal suturing and knot-tying

    Pagina :S83

    Kent R. Van Sickle, E. Matt Ritter, Mercedeh Baghai, Adam Goldenberg, Ih-Ping Huang, Anthony G. Gallagher, C. Daniel Smith

    Mappa Mappa
  • ·Training and assessment of basic suturing skills for fourth year medical students entering surgical residency

    Pagina :S83

    Richard A. Pierce, Deron Tessier, Debra Tiemann, Jennifer Spitler, Brent Matthews, L. Michael Brunt

    Mappa Mappa
  • ·Surgical resident performance on a virtual reality simulator correlates with operating room performance

    Pagina :S84

    Eyad Wohaibi, Eyad Wohaibi, David Earle, Neal Seymour

    Mappa Mappa
  • ·Proficiency-based training: Parameters educators should consider

    Pagina :S84

    Ryan Brydges, Allison Kurahashi, Vera Brümmer, Lisa Satterthwaite, Roger Classen, Adam Dubrowski

    Mappa Mappa
  • ·Computer-based, game show-format interactive lectures: An alternative to didactic education

    Pagina :S84

    Robert G. Neumann, Valerie Halpin, Mary Klingensmith

    Mappa Mappa
  • ·Interactive multi-site video teleconferencing as a means to increase surgical resident and staff participation at core teaching conferences

    Pagina :S85

    Andrew R. Watson, Kenneth Lee, Timothy Billiar, James Luketich

    Mappa Mappa
  • ·Team play in surgical education: Let simulation help us

    Pagina :S85

    Steven Cohen, Alagappan Annamalai, James Maurer, Ronnie Combs, George Bennedetto, Kenneth Rifkind, Jose Torres, Dan Ruiz, James Turner

    Mappa Mappa
  • ·Objective structured clinical exam reduces variability in the assessment of medical students in surgery clerkships

    Pagina :S85

    Paul N. Suding, Susan C. Ahearn, Samuel E. Wilson, Russell A. Williams

    Mappa Mappa
  • ·Creating a surgical education website: What is most important to the general surgery applicant?

    Pagina :S86

    Felicitas L. Koller, Jeffery B. Dattilo, Margaret J. Tarpley, John L. Tarpley

    Mappa Mappa

• Surgical Oncology

  • ·Melanoma secreted thrombospondin-1 induces regulatory T cells via thrombospondin receptor CD47

    Pagina :S87

    Joel M. Baumgartner, Brent Palmer, Janeen Jordan, Anirban Banerjee, Martin McCarter

    Mappa Mappa
  • ·Hepatocellular cancer loses tgf-beta signaling progenitor/stem cell niche, and is suppressed by crosstalk between TGF-beta and IL-6 signaling pathways

    Pagina :S87

    Krit Kitisin, Yi Tang, Varalakshmi Katuri, Eugene A. Volpe, Jonathan Mendelson, Wilma Jogunoori, Kirti Shetty, Stephen Evans, Bibhuti Mishra, Lopa Mishra, Lynt Johnson

    Mappa Mappa
  • ·Immunotherapy with Ad-LIGHT enhances radiation induced tumor cell death

    Pagina :S87

    Rohit R. Sharma, Youjin Lee, Brian Knab, Mitchell Posner, Yang-Xin Fu, Ralph Weichselbaum

    Mappa Mappa
  • ·Systemic delivery by intravenous injection of gamma-1-34.5-deleted HSV-1 for oncolytic viral therapy

    Pagina :S88

    Michael Y. Shao, Jula Veerapong, Kai Bickenbach, Kerrington D. Smith, Bernard Roizman, Ralph R. Weichselbaum, Mitchell C. Posner

    Mappa Mappa
  • ·NF-kappaB activation in response to doxorubicin induces cIAP-2 expression leading to chemoresistance in human sarcomas

    Pagina :S88

    Brian K. Bednarski, Xiaoyu Ding, Albert Baldwin, Hong Jin Kim

    Mappa Mappa
  • ·Effect of RAGE signaling on colorectal liver metastases

    Pagina :S88

    John Allendorf, Nikalesh Ippagunta, Mark Foster, Jean Emond, Ann Marie Schmidt

    Mappa Mappa
  • ·Oncogenic H-Ras increases glucose metabolism with an induction of glucose transporter GLUT1 and hexokinase 2 expression

    Pagina :S89

    John E. Phay, Sunday Oladapupo, Stephen Koch, Craig Short, Daryl Granner, Richard L. Printz

    Mappa Mappa
  • ·Lymph node status prediction after multi-modal therapy (RCT) in rectal cancer by genome microarray analysis

    Pagina :S89

    Dermot T. McDowell, Fraser Smith, Charles Gilham, Graham Pidgeon, Paul Smith, Orla Sheils, Cian Muldoon, Brian Mehigan, Richard Stephens, M. John Kennedy, John Reynolds

    Mappa Mappa
  • ·Gene expression profiling may predict response to neoadjuvant radiochemotherapy (RCT)

    Pagina :S89

    Dermot T. McDowell, Fraser Smith, Charles Gilham, Graham Pidgeon, Paul Smith, Orla Sheils, Cian Muldoon, Brian Mehigan, Richard Stephens, M. John Kennedy, John Reynolds

    Mappa Mappa
  • ·Alpha-T-catenin, a novel gene involved in cell adhesion, is structurally and epigenetically altered in breast cancer and not in lymph node deposits

    Pagina :S90

    James D. Smith, Maria Meehan, Alo McGoldrick, Michelle Harrison, Orla McCormack, Peter Dervan, John Fitzpatrick, Michael Kerin, Amanda McCann

    Mappa Mappa
  • ·Suberoylanilide hydroxamic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells

    Pagina :S90

    Ning Li, David Greenblatt, Mary Ndiaye, Renata Jaskula-Sztul, Megan Haymart, Muthusamy Kunnimalaiyaan, Herbert Chen

    Mappa Mappa
  • ·Effect of molecular therapeutics on liver regeneration in a murine model

    Pagina :S91

    George Van Buren, Anthony D. Yang, Nikolaos A. Dallas, Michael J. Gray, Sherry J. Lim, Ling Xia, Fan Fan, Yan Wu, Daniel J. Hicklin, Lee M. Ellis

    Mappa Mappa

• Targeted Therapies

  • ·In utero gene delivery of adenovirus encoded TGF-beta3 restores physiologic palatal fusion and rescues cleft palate in a TGF-beta3 knockout mouse

    Pagina :S92

    Ryan M. Spivak, Masayuki Endo, Allison Zajac, Philip Zoltick, Brian Ang, Rebecca Horn, Alan Flake, Richard Kirschner, Hyun-Duck Nah

    Mappa Mappa
  • ·Muscle-derived GDNF facilitates motor nerve recovery following sciatic nerve crush injury

    Pagina :S92

    Terence M. Myckatyn, Christina Kenney, Alice Tong, Jessica Duan, Daniel Hunter, Alexander Parsadanian, Susan Mackinnon

    Mappa Mappa
  • ·Eukaryotic Initiation Factor 4E (eIF4E) can be effectively downregulated using small interfering RNA (siRNA), inhibiting growth in breast cancer cells

    Pagina :S92

    Alpana Soni, Argun Akcakanat, Funda Meric-Bernstam

    Mappa Mappa
  • ·Novel role of tyrosine kinase inhibition in the prevention of immune tolerance with immune modulated therapy in advanced malignancy

    Pagina :S93

    Junko J. Ozao, Ping-Ying Pan, George Wang, BingJiao Yin, Celia M. Divino, Shu-Hsia Chen

    Mappa Mappa
  • ·Gene silencing of apoptosis-inducing factor blocks the chemosensitizing effects of the nitric oxide donor DETA/NONOate in metastatic colon cancer cells

    Pagina :S93

    Sergio Huerta, Sapna Chilka, Alejandro Vega, Fernando Rivera, Thomas Anthony, Edward Livingston

    Mappa Mappa
  • ·Activation of Ras/MAPK and mTOR pathways in hepatocellular carcinoma: Tumor growth inhibition with Ras/mTOR pathway abrogation by a novel combination of Sorafenib and rapamycin

    Pagina :S93

    Philippa H. Newell, Augusto Villanueva, Judit Peix, Isabel Fiel, Swan Thung, Steven Yea, Sasan Roayaie, Myron Schwartz, Scott Friedman, Josep Llovet

    Mappa Mappa
  • ·Triptolide a potential therapeutic candidate for pancreatic cancer

    Pagina :S94

    Phoebe Phillips, Daniel Borja-Cacho, Vikas Dudeja, Joshua McCarroll, Rajinder Dawra, William Grizzle, Selwyn Vickers, Ashok Saluja

    Mappa Mappa
  • ·A specific VEGF-R tyrosine kinase inhibitor enhances the antiproliferative effect of trastuzumab in ErbB-2 overexpressing breast cancer cells

    Pagina :S94

    Elizabeth Min Hui Kim, Catherine Lobocki, Linda Dubay, Vijay Mittal

    Mappa Mappa
  • ·Inhibition of an extracellular matrix protein increases survival in orthotopic nude mouse models

    Pagina :S95

    Christine M. Ham, Janine T. Erler, Amato J. Giaccia, Micheal T. Longaker, George P. Yang

    Mappa Mappa
  • ·Exogenous IL-10 treatment prevents from postoperative ileus

    Pagina :S95

    Burkhard Stoffels, Joachim Schmidt, Savanh Chanthaphavong, Solomon Pollard-Bey, Anthony Bauer

    Mappa Mappa
  • ·Delayed NF-kappaB inhibition still provides cardioprotection from myocardial ischemia and reperfusion

    Pagina :S95

    Nancy C. Moss, William E. Stansfield, Ruhang Tang, Craig H. Selzman

    Mappa Mappa
  • ·HoxD10 over-expression impairs recovery in murine model of hindlimb ischemia

    Pagina :S96

    John S. Lane, Tyler Chan, Gemma Arderiu, Louis M. Messina, Nancy J. Boudreau

    Mappa Mappa

• Transplantation

  • ·Respiratory viral infections (RVI) predispose to chronic human lung allograft rejection (BOS) by inducing apoptosis of CD4+CD25+foxp3+ regulatory T cells (Tregs) through airway epithelial cells (AEC)

    Pagina :S97

    Ankit Bharat, Ryan Fields, Elbert Kuo, Michael Walter, William Chapman, G.A. Patterson, T. Mohanakumar

    Mappa Mappa
  • ·17beta-estradiol administration after ischemia preserves funciton and viability by nongenomic mechanisms

    Pagina :S97

    Paul R. Crisostomo, Andrew M. Terrell, Troy Markel, Meijing Wang, Daniel R. Meldrum

    Mappa Mappa
  • ·Transplantation of organs from DCD donors is associated with an accelerated early immune response

    Pagina :S97

    Christian Denecke, Zeki Acun, Anke Jurisch, Aurora Morariu, Steven McGuire, Sayeed Malek, Katja Kotsch, Stefan Tullius

    Mappa Mappa
  • ·Accommodation of intraislet endothelial cells (IEC) confers resistance to hyperacute islet allograft rejection

    Pagina :S98

    Ankit Bharat, Jeremy Goodman, Niraj Desai, William Chapman, T. Mohanakumar

    Mappa Mappa
  • ·Organ quality and unspecific inflammatory graft damage accelerate the early immune response in renal allograft recipients: Synergistic effect of brain death (BD) and donor age

    Pagina :S98

    Aurora M. Morariu, Paulo Martins, Henri Leuvenink, Christian Denecke, Steven McGuire, Zeki Acun, Sayeed Malek, Rutger P. Loeg, Stefan Tullius

    Mappa Mappa
  • ·Disparate patient survival among UNOS regions after liver transplantation for hepatocellular carcinoma

    Pagina :S99

    Siddharth A. Patel, Richard Freeman, Mark Orloff, George Tsoulfas, Randeep Kashyap, Ashok Jain, Adel Bozorgzadeh, Peter Abt

    Mappa Mappa
  • ·Toll-like receptor 4 (TLR4) signaling by both graft and recipient cells is necessary for maximal inflammation after cardiac cold ischemia-reperfusion

    Pagina :S99

    David Kaczorowski, Atsunori Nakao, Kevin Mollen, Raghuveer Vallabhaneni, Brian Zuckerbraun, Kenneth McCurry, Noriko Murase, Timothy Billiar

    Mappa Mappa
  • ·CXCR3 receptor knockout mice are protected from liver warm ischemia-reperfusion injury

    Pagina :S100

    Elizabeth R. Benjamin, Andrew Vardanian, Xiu-Da Shen, Feng Gao, Yuan Zhai, Jerzy Kupiec-Weglinski, Ronald Busuttil

    Mappa Mappa
  • ·Prolongation of rodent hind limb allografts with topical tacrolimus after total withdrawal of systemic immunosuppression

    Pagina :S100

    Mario G. Solari, Kia M. McLean, Justin M. Sacks, Teresa Hautz, Jignesh Unadkat, Elaine K. Horibe, Vijay S. Gorantla, Stefan Schneeberger, W.P. Andrew Lee

    Mappa Mappa
  • ·Delayed gratification: A program of intimal hyperplasia progresses even as graft antigen-specific CD4+ T cells subside

    Pagina :S101

    Stephen J. Huddleston, Elizabeth Ingulli, Marc K. Jenkins

    Mappa Mappa
  • ·Quantification of functional outcome in the rat hemifacial allotransplantion model

    Pagina :S101

    Kia M. McLean, Mario G. Solari, Justin M. Sacks, Elaine K. Horibe, Jignesh V. Unadkat, Vijay S. Gorantla, Stefan Schneeberger, George E. Carvell, Daniel J. Simons, W.P. Andrew Lee

    Mappa Mappa
  • ·Distinct CXCR3 chemokine induction patterns during cold and warm ischemia in liver transplantation

    Pagina :S101

    Andrew J. Vardanian, Elizabeth R. Benjamin, Yuan Zhai, Xiu-da Shen, Feng Gao, Jerzy W. Kupiec-Weglinski, Ronald W. Busuttil

    Mappa Mappa

• Urology/Reproductive Biology

  • ·PPARgamma agonist GW1929 inhibits proliferation, induces apoptosis, and decreases invasiveness of prostate cancer cells

    Pagina :S103

    Yekaterina A. Koshkareva, M. Alexandra Monroy, Ryan Engdahl, Matteo Frasson, Smitha Yerrum, John Daly

    Mappa Mappa
  • ·Antitumor activity of a combined curcumin and TRAIL treatment regimen against prostate cancer xenografts

    Pagina :S103

    Tanja A. Andrzejewski, Dorrah Deeb, Xiaohua Gao, Andrew Danyluk, Scott Dulchavsky, Subhash Gautam

    Mappa Mappa
  • ·Diagnostic rates and other outcomes based on initial versus repeat biopsy in a cohort of men undergoing a modern biopsy (10-12 core) scheme

    Pagina :S103

    Javier Miller, Kelly Swords, Culley Carson, John Lavelle, Eric Wallen, Raj S. Pruthi

    Mappa Mappa
  • ·Tissue bioreactor system for the creation and maturation of organized functional tissues for surgical reconstruction

    Pagina :S104

    Du Geon Moon, Bryan Tillman, George Christ, Joel Stitzel, James Yoo, Anthony Atala

    Mappa Mappa
  • ·Repair of the buried penis: 3-point technique

    Pagina :S104

    Armine Karapetian, Jeffrey S. Palmer

    Mappa Mappa
  • ·Cystectomy in the ninth decade: Operative results and longterm survival outcomes

    Pagina :S104

    Kevin Zorn, Frederick Mendiola, Ofer Gofrit, Albert Mikhail, Marcelo Orvieto, Gary Steinberg

    Mappa Mappa
  • ·Clinical usefulness of serum Ca 125 levels in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder

    Pagina :S105

    Aaron Lentz, Vishal Bhalani, Eric M. Wallen, Raj S. Pruthi

    Mappa Mappa
  • ·Tissue engineering of subcutaneous tunnels with autologous minced epithelium

    Pagina :S105

    Magdalena Fossum, Baraa Zuhaili, Malte Spielmann, Tobias Hirsch, Elof Eriksson

    Mappa Mappa
  • ·Muscle progenitor cells for the restoration of irreversibly damaged sphincter function: A pre-clinical study

    Pagina :S106

    Daniel Eberli, Bryan Tillman, James Yoo, Shay Soker, Anthony Atala

    Mappa Mappa
  • ·Inverted 3D volumetric imaging for enhanced visualization of ureteroceles and ectopic ureters in pediatric patients

    Pagina :S106

    Paul J. Kokorowski, Hollie Jackson, Rex Moats, Lee Schiel, Dawn Berkeley, Theresa Dunway, Brian Hardy, Roger DeFilippo

    Mappa Mappa
  • ·Cost of malignant ureteral obstruction treated with ureteral stents

    Pagina :S106

    Anjali M. Ganatra, Kevin R. Loughlin

    Mappa Mappa
  • ·Subpopulations in human amniotic fluid: A source of progenitor cells for structure specific tissue regeneration

    Pagina :S107

    Stefano Da Sacco, Laura Perin, Sargis Sedrakyan, Casey Brewer, Paul Kokorowski, Francesco Boldrin, Pier Paolo Parnigotto, David Warburton, Roger DeFilippo

    Mappa Mappa

• Vascular Surgery

  • ·Carbon monoxide treated macrophages release a soluble factor that inhibits smooth muscle proliferation

    Pagina :S108

    Jitesh Patel, Chase Gladstone, Edith Tzeng

    Mappa Mappa
  • ·Thermoreversible poloxamers and applications for vascular biology

    Pagina :S108

    Edward I. Chang, Cynthia D. Hamou, Michael G. Galvez, Michael T. Longaker, Geoffrey C. Gurtner

    Mappa Mappa
  • ·HMGB-1 induces pro-angiogenic effects in endothelial cells: Implications for lower extremity ischemia

    Pagina :S108

    Ulka Sachdev, Edith Tzeng

    Mappa Mappa
  • ·Use of services and predictors of readmission after open abdominal aortic aneurysm repair—A population-based analysis

    Pagina :S109

    Janak A. Parikh, Michael Leonardi, Sushma Jain, Marcia McGory, David Zingmond, Clifford Ko

    Mappa Mappa
  • ·Increased proliferation rates of fetal endothelial cells may limit inflammation and scar following injury

    Pagina :S109

    Jean E. Hsu, Roma Patel, Brian J. Williams, Oluyinka O. Olutoye, C. Wayne Smith, Darrell L. Cass

    Mappa Mappa
  • ·Ischemic colitis complicating open vs endovascular abdominal aortic aneurysm repair

    Pagina :S110

    Jason T. Perry, Matthew Martin, Matthew Eckert, Vance Sohn, Scott Steele

    Mappa Mappa
  • ·Gait abnormalities are present prior to the onset of claudication in both young and old claudicants

    Pagina :S110

    Rolando Celis, Huisinga Jessie, Pipinos Iraklis, G. Matthew Longo, Thomas Lynch, Nicholas Stergiou, Jason Johanning

    Mappa Mappa
  • ·Development of a novel animal model of paralysis in thoracic aortic endovascular repair

    Pagina :S110

    Mark L. Manwaring, Dorian J. deFreitas, Clark M. Kardys, D. Wesley Hudson, Ricardo M. Mendoza, Charles S. Powell, Frank M. Parker, Curtis A. Anderson, W. Randolph Chitwood, Michael C. Stoner

    Mappa Mappa
  • ·Rapamycin regulates synthesis of transforming growth factor-beta1 and extracellular matrix in arterial neointimal smooth muscle cells

    Pagina :S111

    Jeffery L. Walding, Jing Kang, Daniel Day, Martin Dalton, Walter Newman, Zhongbiao Wang

    Mappa Mappa
  • ·AneuMastat reduces aneurysm incidence in the angiotensin II (AngII)-induced model of abdominal aortic aneurysm (AAA) in the wildtype C57BL6 mouse

    Pagina :S111

    Leslie S. Tyrie, Kana Fujikura, Jianwen Luo, Sorin Selegean, Marc Attiyeh, Peter Collin, Elisa Konofagou, Harold Gaetz, M.D. Tilson

    Mappa Mappa
  • ·Clinical impact of transrenal fixation during endovascular aneurysm repair on renal function

    Pagina :S111

    Zachary Arthurs, Vance Sohn, Jason Perry, Matthew Eckert, Charles Andersen, Benjamin Starnes

    Mappa Mappa
  • ·Angiotensin-converting enzyme inhibitor reduces proadhesive activity of neointimal smooth muscle cells through attenuating constitutive NF-kB activity

    Pagina :S112

    William C. Streetman, Andrew Foret, Mark Herndon, Jing Kang, Walter Newman, Martin Dalton, Zhongbiao Wang

    Mappa Mappa